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    NOTO notochord homeobox [ Homo sapiens (human) ]

    Gene ID: 344022, updated on 12-Jun-2019

    Summary

    Official Symbol
    NOTOprovided by HGNC
    Official Full Name
    notochord homeoboxprovided by HGNC
    Primary source
    HGNC:HGNC:31839
    See related
    Ensembl:ENSG00000214513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See NOTO in Genome Data Viewer
    Location:
    2p13.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (73202258..73211212)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73429386..73438340)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sideroflexin 5 Neighboring gene uncharacterized LOC105374800 Neighboring gene RAB11 family interacting protein 5 Neighboring gene SMYD family member 5 Neighboring gene protease associated domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    notochord development IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    homeobox protein notochord
    Names
    notochord homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134462.2NP_001127934.1  homeobox protein notochord

      See identical proteins and their annotated locations for NP_001127934.1

      Status: VALIDATED

      Source sequence(s)
      AC010913, AK295936
      Consensus CDS
      CCDS46335.1
      UniProtKB/Swiss-Prot
      A8MTQ0
      Related
      ENSP00000381486.3, ENST00000398468.3
      Conserved Domains (1) summary
      pfam00046
      Location:160211
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

      Range
      73202258..73211212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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