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    ZSCAN22 zinc finger and SCAN domain containing 22 [ Homo sapiens (human) ]

    Gene ID: 342945, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZSCAN22provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 22provided by HGNC
    Primary source
    HGNC:HGNC:4929
    See related
    Ensembl:ENSG00000182318 MIM:165260; AllianceGenome:HGNC:4929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HKR2; ZNF50
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See ZSCAN22 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58326994..58342332)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61423408..61438747)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58838360..58853698)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF8-ERVK3-1 readthrough (NMD candidate) Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58816949-58817449 Neighboring gene Sharpr-MPRA regulatory region 7439 Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480 Neighboring gene zinc finger protein 470 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58838245-58838987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58849877-58850378 Neighboring gene microRNA 6806 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58858160-58858660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58858661-58859161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15186 Neighboring gene alpha-1-B glycoprotein Neighboring gene A1BG antisense RNA 1 Neighboring gene zinc finger protein 446 pseudogene Neighboring gene zinc finger protein 497

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126679, MGC138482

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and SCAN domain-containing protein 22
    Names
    GLI-Kruppel family member HKR2
    krueppel-related zinc finger protein 2
    zinc finger protein 50

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321116.2NP_001308045.1  zinc finger and SCAN domain-containing protein 22 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010642, AC012313, AK128716
      Consensus CDS
      CCDS12975.1
      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8
      Conserved Domains (3) summary
      COG5048
      Location:174482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45129
      SCAN; SCAN domain
    2. NM_001321117.2NP_001308046.1  zinc finger and SCAN domain-containing protein 22 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010642, AC012313, AK128716, BC143446, DA335630
      UniProtKB/Swiss-Prot
      P10073
      Conserved Domains (2) summary
      smart00431
      Location:45153
      SCAN; leucine rich region
      pfam02023
      Location:45130
      SCAN; SCAN domain
    3. NM_181846.3NP_862829.1  zinc finger and SCAN domain-containing protein 22 isoform 1

      See identical proteins and their annotated locations for NP_862829.1

      Status: VALIDATED

      Source sequence(s)
      AC010642, AC012313, BC112277
      Consensus CDS
      CCDS12975.1
      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8
      Related
      ENSP00000332433.3, ENST00000329665.5
      Conserved Domains (3) summary
      COG5048
      Location:174482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45129
      SCAN; SCAN domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58326994..58342332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526917.3XP_011525219.1  zinc finger and SCAN domain-containing protein 22 isoform X1

      See identical proteins and their annotated locations for XP_011525219.1

      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8
      Conserved Domains (3) summary
      COG5048
      Location:174482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45129
      SCAN; SCAN domain
    2. XM_006723192.4XP_006723255.1  zinc finger and SCAN domain-containing protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006723255.1

      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8
      Conserved Domains (3) summary
      COG5048
      Location:174482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:45129
      SCAN; SCAN domain
    3. XM_017026746.2XP_016882235.1  zinc finger and SCAN domain-containing protein 22 isoform X2

      Conserved Domains (2) summary
      smart00431
      Location:45153
      SCAN; leucine rich region
      pfam02023
      Location:45130
      SCAN; SCAN domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61423408..61438747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320852.1XP_054176827.1  zinc finger and SCAN domain-containing protein 22 isoform X2

    2. XM_054320850.1XP_054176825.1  zinc finger and SCAN domain-containing protein 22 isoform X1

      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8
    3. XM_054320851.1XP_054176826.1  zinc finger and SCAN domain-containing protein 22 isoform X1

      UniProtKB/Swiss-Prot
      P10073, Q15922, Q7Z3L8