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    LEUTX leucine twenty homeobox [ Homo sapiens (human) ]

    Gene ID: 342900, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LEUTXprovided by HGNC
    Official Full Name
    leucine twenty homeoboxprovided by HGNC
    Primary source
    HGNC:HGNC:31953
    See related
    Ensembl:ENSG00000213921 MIM:618701; AllianceGenome:HGNC:31953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See LEUTX in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39776453..39786291)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42580718..42590554)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40267093..40276931)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14629 Neighboring gene galectin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14630 Neighboring gene Charcot-Leyden crystal galectin Neighboring gene uncharacterized LOC124904719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40314468-40315454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40315455-40316439 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human PRD-like homeobox gene LEUTX has a central role in embryo genome activation. Jouhilahti EM, et al. Development, 2016 Oct 1. PMID 27578796, Free PMC Article
    2. Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates. Lewin TD, et al. Genome Biol Evol, 2023 Jun 1. PMID 37232378, Free PMC Article
    3. Classification and nomenclature of all human homeobox genes. Holland PW, et al. BMC Biol, 2007 Oct 26. PMID 17963489, Free PMC Article
    4. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
      Title: Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
    2. Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates.
      Title: Rapid Evolution of the Embryonically Expressed Homeobox Gene LEUTX within Primates.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    paired-like homeodomain transcription factor LEUTX
    Names
    PRD-LIKE homeobox transcription factor LEUTX
    arginine-fifty homeobox-like pseudogene
    paired-like homeobox transcription factor LEUTX
    putative leucine-twenty homeobox

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143832.2 → NP_001137304.1  paired-like homeodomain transcription factor LEUTX isoform 2

      See identical proteins and their annotated locations for NP_001137304.1

      Status: VALIDATED

      Source sequence(s)
      AC005393
      UniProtKB/Swiss-Prot
      A8MZ59
      Related
      ENSP00000380053.3, ENST00000396841.4
      Conserved Domains (1) summary
      pfam00046
      Location:1 → 34
      Homeobox; Homeobox domain

    2. NM_001382345.1 → NP_001369274.1  paired-like homeodomain transcription factor LEUTX isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC005393
      Consensus CDS
      CCDS92615.1
      UniProtKB/Swiss-Prot
      A0A1W2PQ33, A8MZ59
      Related
      ENSP00000491740.1, ENST00000638280.2
      Conserved Domains (1) summary
      smart00389
      Location:15 → 64
      HOX; Homeodomain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39776453..39786291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      36329..46167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42580718..42590554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003931.1: Suppressed sequence

      Description
      NR_003931.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MZ59.4 GenPept UniProtKB/Swiss-Prot:A8MZ59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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