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    IDH1 isocitrate dehydrogenase (NADP(+)) 1 [ Homo sapiens (human) ]

    Gene ID: 3417, updated on 22-Jan-2023

    Summary

    Official Symbol
    IDH1provided by HGNC
    Official Full Name
    isocitrate dehydrogenase (NADP(+)) 1provided by HGNC
    Primary source
    HGNC:HGNC:5382
    See related
    Ensembl:ENSG00000138413 MIM:147700; AllianceGenome:HGNC:5382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26
    Summary
    Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
    Expression
    Ubiquitous expression in adrenal (RPKM 116.0), liver (RPKM 110.2) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IDH1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (208236227..208255071, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208716002..208734866, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (209100951..209119795, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene 27 Neighboring gene TPT1 pseudogene 2 Neighboring gene IDH1 antisense RNA 1 Neighboring gene phosphoinositide kinase, FYVE-type zinc finger containing Neighboring gene MYL6B pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
    Knockdown of isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables isocitrate dehydrogenase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in NADP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in female gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glyoxylate cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isocitrate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisomal matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    isocitrate dehydrogenase [NADP] cytoplasmic
    Names
    NADP(+)-specific ICDH
    NADP-dependent isocitrate dehydrogenase, cytosolic
    NADP-dependent isocitrate dehydrogenase, peroxisomal
    epididymis luminal protein 216
    epididymis secretory protein Li 26
    epididymis secretory sperm binding protein
    isocitrate dehydrogenase (NADP(+)) 1, cytosolic
    isocitrate dehydrogenase 1 (NADP+), soluble
    oxalosuccinate decarboxylase
    NP_001269315.1
    NP_001269316.1
    NP_005887.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023319.2 RefSeqGene

      Range
      15932..34848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_610

    mRNA and Protein(s)

    1. NM_001282386.1NP_001269315.1  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_001269315.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC021046, DA707595, N21575
      Consensus CDS
      CCDS2381.1
      UniProtKB/Swiss-Prot
      O75874, Q9UKW8
      UniProtKB/TrEMBL
      V9HWJ2
      Related
      ENSP00000410513.1, ENST00000446179.5
      Conserved Domains (1) summary
      PTZ00435
      Location:1411
      PTZ00435; isocitrate dehydrogenase; Provisional
    2. NM_001282387.1NP_001269316.1  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_001269316.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC012846, DR158630, N21575
      Consensus CDS
      CCDS2381.1
      UniProtKB/Swiss-Prot
      O75874, Q9UKW8
      UniProtKB/TrEMBL
      V9HWJ2
      Related
      ENSP00000390265.1, ENST00000415913.5
      Conserved Domains (1) summary
      PTZ00435
      Location:1411
      PTZ00435; isocitrate dehydrogenase; Provisional
    3. NM_005896.4NP_005887.2  isocitrate dehydrogenase [NADP] cytoplasmic

      See identical proteins and their annotated locations for NP_005887.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC016697, BC021046, DA728868
      Consensus CDS
      CCDS2381.1
      UniProtKB/Swiss-Prot
      O75874, Q9UKW8
      UniProtKB/TrEMBL
      V9HWJ2
      Related
      ENSP00000260985.2, ENST00000345146.7
      Conserved Domains (1) summary
      PTZ00435
      Location:1411
      PTZ00435; isocitrate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      208236227..208255071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      208716002..208734866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)