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    STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]

    Gene ID: 340061, updated on 26-Oct-2021

    Summary

    Official Symbol
    STING1provided by HGNC
    Official Full Name
    stimulator of interferon response cGAMP interactor 1provided by HGNC
    Primary source
    HGNC:HGNC:27962
    See related
    Ensembl:ENSG00000184584 MIM:612374
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta
    Summary
    This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues See more
    Orthologs
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    Genomic context

    See STING1 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139475533..139482758, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138855118..138862343, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33 Neighboring gene cancer-related nucleoside-triphosphatase pseudogene Neighboring gene nuclear receptor coactivator 4 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    GeneReviews: Not available
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    GeneReviews: Not available
    Sting-associated vasculopathy, infantile-onset
    MedGen: C4014722 OMIM: 615934 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr antagonizes TMEM173 (STING)-mediated innate immune recognition in TZM-bl STING cells (TZM-bl cells engineered to express TMEM173 (STING)) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38577

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2',3'-cyclic GMP-AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 2',3'-cyclic GMP-AMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2',3'-cyclic GMP-AMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclic-di-GMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclic-di-GMP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to exogenous dsRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein complex oligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in reticulophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in reticulophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    stimulator of interferon genes protein
    Names
    N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
    endoplasmic reticulum IFN stimulator
    endoplasmic reticulum interferon stimulator
    mitochondrial mediator of IRF3 activation
    stimulator of interferon protein
    transmembrane protein 173

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034249.1 RefSeqGene

      Range
      5033..12258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1308

    mRNA and Protein(s)

    1. NM_001301738.2NP_001288667.1  stimulator of interferon genes protein isoform 2

      See identical proteins and their annotated locations for NP_001288667.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, resulting in a frameshift. The encoded isoform (2) has a shorter and distinct C-terminus.
      Source sequence(s)
      AC138517, BI905932, BM708269, BM981219, KF430638
      UniProtKB/TrEMBL
      V5V0K2
      Related
      ENSP00000498513.1, ENST00000652110.1
      Conserved Domains (1) summary
      pfam15009
      Location:44253
      TMEM173; Transmembrane protein 173
    2. NM_001367258.1NP_001354187.1  stimulator of interferon genes protein isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a coding exon, resulting in a different 5' UTR, and the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC138517
      Related
      ENSP00000498768.1, ENST00000651565.1
      Conserved Domains (1) summary
      pfam15009
      Location:1218
      TMEM173; Transmembrane protein 173
    3. NM_198282.4NP_938023.1  stimulator of interferon genes protein isoform 1

      See identical proteins and their annotated locations for NP_938023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC047779, BI905932, BM981219
      Consensus CDS
      CCDS4215.1
      UniProtKB/Swiss-Prot
      Q86WV6
      Related
      ENSP00000331288.4, ENST00000330794.9
      Conserved Domains (1) summary
      pfam15009
      Location:44337
      TMEM173; Transmembrane protein 173

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      139475533..139482758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537639.3XP_011535941.1  stimulator of interferon genes protein isoform X2

      Conserved Domains (1) summary
      pfam15009
      Location:44253
      TMEM173; Transmembrane protein 173

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_021159996.1 Reference GRCh38.p13 PATCHES

      Range
      65328..72553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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