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    ZNF546 zinc finger protein 546 [ Homo sapiens (human) ]

    Gene ID: 339327, updated on 19-Jun-2019

    Summary

    Official Symbol
    ZNF546provided by HGNC
    Official Full Name
    zinc finger protein 546provided by HGNC
    Primary source
    HGNC:HGNC:28671
    See related
    Ensembl:ENSG00000187187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF49
    Expression
    Broad expression in testis (RPKM 3.3), thyroid (RPKM 0.9) and 22 other tissues See more
    Orthologs

    Genomic context

    See ZNF546 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (39997060..40021038)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40502943..40523514)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987267 Neighboring gene proline rich 13 pseudogene 5 Neighboring gene proteasome 26S subunit, ATPase 4 Neighboring gene Sharpr-MPRA regulatory region 7932 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene zinc finger protein 780B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    General gene information

    Markers

    Homology

    Clone Names

    • MGC43537

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 546
    Names
    CTC-471F3.6
    zinc finger protein 49

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297763.2NP_001284692.1  zinc finger protein 546 isoform 2

      See identical proteins and their annotated locations for NP_001284692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC007842, AF087985, AK122968, AK292528, DA217689
      Consensus CDS
      CCDS77297.1
      UniProtKB/Swiss-Prot
      Q86UE3
      UniProtKB/TrEMBL
      B3KVL3, M0QY24
      Related
      ENSP00000469540.1, ENST00000600094.5
      Conserved Domains (5) summary
      smart00349
      Location:3494
      KRAB; krueppel associated box
      COG5048
      Location:357797
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3473
      KRAB; KRAB box
      pfam13465
      Location:625650
      zf-H2C2_2; Zinc-finger double domain
    2. NM_178544.5NP_848639.2  zinc finger protein 546 isoform 1

      See identical proteins and their annotated locations for NP_848639.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007842, AF087985, AK122968, AK292528, DA217689
      Consensus CDS
      CCDS12548.1
      UniProtKB/Swiss-Prot
      Q86UE3
      UniProtKB/TrEMBL
      B3KVL3
      Related
      ENSP00000339823.3, ENST00000347077.9
      Conserved Domains (5) summary
      smart00349
      Location:60120
      KRAB; krueppel associated box
      COG5048
      Location:383823
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:583603
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6099
      KRAB; KRAB box
      pfam13465
      Location:651676
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      39997060..40021038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p13 PATCHES

      Range
      272203..296181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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