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    CHSY3 chondroitin sulfate synthase 3 [ Homo sapiens (human) ]

    Gene ID: 337876, updated on 17-Jun-2019

    Summary

    Official Symbol
    CHSY3provided by HGNC
    Official Full Name
    chondroitin sulfate synthase 3provided by HGNC
    Primary source
    HGNC:HGNC:24293
    See related
    Ensembl:ENSG00000198108 MIM:609963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSS3; CHSY2
    Summary
    CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See CHSY3 in Genome Data Viewer
    Location:
    5q23.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (129903384..130186637)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (129240389..129522327)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAMTS19 antisense RNA 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 19 Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene uncharacterized LOC112267944 Neighboring gene RNA, U6atac small nuclear 10, pseudogene Neighboring gene uncharacterized LOC105379170 Neighboring gene RNA, 5S ribosomal pseudogene 191 Neighboring gene Sharpr-MPRA regulatory region 1157 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 4 Neighboring gene uncharacterized LOC105379171 Neighboring gene RNA, U7 small nuclear 53 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    chondroitin sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chondroitin sulfate synthase 3
    Names
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
    N-acetylgalactosaminyltransferase 3
    carbohydrate synthase 2
    chSy-2
    chondroitin glucuronyltransferase 3
    chondroitin synthase-2
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
    NP_787052.3
    XP_005272039.1
    XP_005272040.1
    XP_011541665.1
    XP_011541666.1
    XP_011541667.1
    XP_016864923.1
    XP_016864924.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175856.5NP_787052.3  chondroitin sulfate synthase 3

      See identical proteins and their annotated locations for NP_787052.3

      Status: VALIDATED

      Source sequence(s)
      AB086062, AC011360, AJ504664, AJ578034
      Consensus CDS
      CCDS34223.1
      UniProtKB/Swiss-Prot
      Q70JA7
      Related
      ENSP00000302629.4, ENST00000305031.5
      Conserved Domains (2) summary
      pfam05679
      Location:328864
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      cl21608
      Location:173398
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      129903384..130186637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543363.3XP_011541665.1  chondroitin sulfate synthase 3 isoform X1

      Conserved Domains (1) summary
      pfam05679
      Location:19555
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
    2. XM_011543365.3XP_011541667.1  chondroitin sulfate synthase 3 isoform X4

      Conserved Domains (2) summary
      cl11394
      Location:328369
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
      cl21608
      Location:173351
      Galactosyl_T; Galactosyltransferase
    3. XM_005271982.4XP_005272039.1  chondroitin sulfate synthase 3 isoform X5

      Conserved Domains (2) summary
      cl11394
      Location:328362
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
      cl21608
      Location:173351
      Galactosyl_T; Galactosyltransferase
    4. XM_017009435.2XP_016864924.1  chondroitin sulfate synthase 3 isoform X3

    5. XM_005271983.4XP_005272040.1  chondroitin sulfate synthase 3 isoform X6

      Conserved Domains (2) summary
      cl11394
      Location:328363
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
      cl21608
      Location:173351
      Galactosyl_T; Galactosyltransferase
    6. XM_017009434.1XP_016864923.1  chondroitin sulfate synthase 3 isoform X2

      Conserved Domains (1) summary
      pfam05679
      Location:1502
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
    7. XM_011543364.2XP_011541666.1  chondroitin sulfate synthase 3 isoform X2

      Conserved Domains (1) summary
      pfam05679
      Location:1502
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
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