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    PRMT1 protein arginine methyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 3276, updated on 21-Jan-2020

    Summary

    Official Symbol
    PRMT1provided by HGNC
    Official Full Name
    protein arginine methyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:5187
    See related
    Ensembl:ENSG00000126457 MIM:602950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANM1; HCP1; IR1B4; HRMT1L2
    Summary
    This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in ovary (RPKM 42.8), heart (RPKM 38.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See PRMT1 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49676166..49688450)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50180409..50191707)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 1 Neighboring gene interferon regulatory factor 3 Neighboring gene BCL2 like 12 Neighboring gene microRNA 5088 Neighboring gene adrenomedullin 5 (putative) Neighboring gene carnitine palmitoyltransferase 1C Neighboring gene CRISPRi-validated cis-regulatory element chr19.5489

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    nucleocapsid gag HIV-1 NC is identified to have a physical interaction with protein arginine methyltransferase 1 (PRMT1; ANM1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    N-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA binding HDA PubMed 
    S-adenosyl-L-methionine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity (H4-R3 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity (H4-R3 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    identical protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    methyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    mitogen-activated protein kinase p38 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-arginine N-methyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein-arginine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-arginine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    protein-arginine omega-N asymmetric methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-arginine omega-N asymmetric methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein-arginine omega-N monomethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    histone H4-R3 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4-R3 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-arginine methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hemoglobin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of p38MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of megakaryocyte differentiation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    methylosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein arginine N-methyltransferase 1
    Names
    HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2
    heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2
    histone-arginine N-methyltransferase PRMT1
    interferon receptor 1-bound protein 4
    NP_001193971.1
    NP_001527.3
    NP_938074.2
    XP_005258899.1
    XP_016882223.1
    XP_016882224.1
    XP_016882225.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031846.1 RefSeqGene

      Range
      5001..16299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207042.2NP_001193971.1  protein arginine N-methyltransferase 1 isoform 4

      See identical proteins and their annotated locations for NP_001193971.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AI193116, BX352789, DC421815
      Consensus CDS
      CCDS74425.1
      UniProtKB/TrEMBL
      A0A087X1W2
      Related
      ENSP00000484505.1, ENST00000610806.4
      Conserved Domains (1) summary
      cd02440
      Location:74143
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_001536.5NP_001527.3  protein arginine N-methyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_001527.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI193116, AK304660, DC421815, Y10806
      Consensus CDS
      CCDS46145.1
      UniProtKB/Swiss-Prot
      Q99873
      UniProtKB/TrEMBL
      H7C2I1
      Related
      ENSP00000406162.2, ENST00000454376.6
      Conserved Domains (1) summary
      cd02440
      Location:92192
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. NM_198318.4NP_938074.2  protein arginine N-methyltransferase 1 isoform 3

      See identical proteins and their annotated locations for NP_938074.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AI193116, DC421815, Y10807
      Consensus CDS
      CCDS42592.1
      UniProtKB/Swiss-Prot
      Q99873
      Related
      ENSP00000375724.4, ENST00000391851.8
      Conserved Domains (1) summary
      cd02440
      Location:74174
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. NR_033397.4 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI193116, CN264743, CR407608, DC421815

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      49676166..49688450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026736.1XP_016882225.1  protein arginine N-methyltransferase 1 isoform X2

      Related
      ENSP00000433556.1, ENST00000532489.5
      Conserved Domains (1) summary
      cd02440
      Location:63163
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. XM_017026735.1XP_016882224.1  protein arginine N-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99873
      Conserved Domains (1) summary
      cd02440
      Location:68168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    3. XM_017026734.1XP_016882223.1  protein arginine N-methyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q99873
      Conserved Domains (1) summary
      cd02440
      Location:68168
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    4. XM_005258842.1XP_005258899.1  protein arginine N-methyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_005258899.1

      Conserved Domains (1) summary
      cd02440
      Location:63163
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198319.2: Suppressed sequence

      Description
      NM_198319.2: This RefSeq was permanently suppressed because it contains a uORF at nt 43..240 that is predicted to inhibit translation of the annotated CDS.
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