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    HOXB7 homeobox B7 [ Homo sapiens (human) ]

    Gene ID: 3217, updated on 15-Jun-2019

    Summary

    Official Symbol
    HOXB7provided by HGNC
    Official Full Name
    homeobox B7provided by HGNC
    Primary source
    HGNC:HGNC:5118
    See related
    Ensembl:ENSG00000260027 MIM:142962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX2; HOX2C; HHO.C1; Hox-2.3
    Summary
    This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 10.0), colon (RPKM 8.7) and 15 other tissues See more
    Orthologs

    Genomic context

    See HOXB7 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (48607232..48611021, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46684594..46688383, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5 Neighboring gene homeobox B6 Neighboring gene homeobox B8 Neighboring gene homeobox B9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    embryonic skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    myeloid cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Hox-B7
    Names
    homeo box 2C
    homeo box B7
    homeo box c1 protein
    homeobox protein HHO.C1
    homeobox protein Hox-2C

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004502.4NP_004493.3  homeobox protein Hox-B7

      See identical proteins and their annotated locations for NP_004493.3

      Status: REVIEWED

      Source sequence(s)
      BG118354, BM923808, BP342702, BQ233410
      Consensus CDS
      CCDS11532.1
      UniProtKB/Swiss-Prot
      P09629
      Related
      ENSP00000239165.7, ENST00000239165.8
      Conserved Domains (1) summary
      pfam00046
      Location:141193
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      48607232..48611017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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