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    HOXB3 homeobox B3 [ Homo sapiens (human) ]

    Gene ID: 3213, updated on 17-Jun-2019

    Summary

    Official Symbol
    HOXB3provided by HGNC
    Official Full Name
    homeobox B3provided by HGNC
    Primary source
    HGNC:HGNC:5114
    See related
    Ensembl:ENSG00000120093 MIM:142966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOX2; HOX2G; Hox-2.7
    Summary
    This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in kidney (RPKM 1.6), fat (RPKM 1.3) and 21 other tissues See more
    Orthologs

    Genomic context

    See HOXB3 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (48548870..48590272, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46626232..46667634, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4554 Neighboring gene HOXB cluster antisense RNA 1 Neighboring gene homeobox B2 Neighboring gene homeobox B4 Neighboring gene microRNA 10a Neighboring gene HOXB cluster antisense RNA 3 Neighboring gene homeobox B5 Neighboring gene homeobox B6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of homeobox B3 (HOXB3) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    face development IEA
    Inferred from Electronic Annotation
    more info
     
    glossopharyngeal nerve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    rhombomere development IEA
    Inferred from Electronic Annotation
    more info
     
    thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Hox-B3
    Names
    homeo box 2G
    homeobox protein Hox-2.7
    homeobox protein Hox-2G

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330322.2NP_001317251.1  homeobox protein Hox-B3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK299265, AK316245, CN430280, CN430281
      Consensus CDS
      CCDS82154.1
      UniProtKB/Swiss-Prot
      P14651
      Related
      ENSP00000418729.1, ENST00000489475.5
    2. NM_001330323.1NP_001317252.1  homeobox protein Hox-B3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK299226, AK316245, CN430280, CN430281, DA748374
      Consensus CDS
      CCDS82153.1
      UniProtKB/Swiss-Prot
      P14651
      Related
      ENSP00000418035.1, ENST00000460160.5
      Conserved Domains (2) summary
      pfam00046
      Location:60112
      Homeobox; Homeobox domain
      pfam13293
      Location:234297
      DUF4074; Domain of unknown function (DUF4074)
    3. NM_002146.4NP_002137.4  homeobox protein Hox-B3 isoform 1

      See identical proteins and their annotated locations for NP_002137.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC103702, AI633956, AK027609, CN358294, DA735249, X16667
      Consensus CDS
      CCDS11528.1
      UniProtKB/Swiss-Prot
      P14651
      UniProtKB/TrEMBL
      B3KNJ7
      Related
      ENSP00000308252.4, ENST00000311626.8
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      48548870..48590272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257277.3XP_005257334.1  homeobox protein Hox-B3 isoform X3

      See identical proteins and their annotated locations for XP_005257334.1

      UniProtKB/Swiss-Prot
      P14651
      Related
      ENSP00000420595.1, ENST00000498678.5
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)
    2. XM_017024560.1XP_016880049.1  homeobox protein Hox-B3 isoform X1

      Conserved Domains (2) summary
      pfam00046
      Location:339391
      Homeobox; Homeobox domain
      pfam13293
      Location:513576
      DUF4074; Domain of unknown function (DUF4074)
    3. XM_011524710.2XP_011523012.1  homeobox protein Hox-B3 isoform X3

      See identical proteins and their annotated locations for XP_011523012.1

      UniProtKB/Swiss-Prot
      P14651
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)
    4. XM_006721854.3XP_006721917.1  homeobox protein Hox-B3 isoform X3

      See identical proteins and their annotated locations for XP_006721917.1

      UniProtKB/Swiss-Prot
      P14651
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)
    5. XM_011524721.3XP_011523023.1  homeobox protein Hox-B3 isoform X4

      Conserved Domains (2) summary
      pfam00046
      Location:191243
      Homeobox; Homeobox domain
      pfam13293
      Location:365428
      DUF4074; Domain of unknown function (DUF4074)
    6. XM_024450737.1XP_024306505.1  homeobox protein Hox-B3 isoform X3

      Related
      ENSP00000417207.1, ENST00000470495.1
    7. XM_011524720.3XP_011523022.1  homeobox protein Hox-B3 isoform X3

      See identical proteins and their annotated locations for XP_011523022.1

      UniProtKB/Swiss-Prot
      P14651
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)
    8. XM_011524708.3XP_011523010.2  homeobox protein Hox-B3 isoform X2

      Conserved Domains (2) summary
      pfam00046
      Location:60112
      Homeobox; Homeobox domain
      pfam13293
      Location:234297
      DUF4074; Domain of unknown function (DUF4074)
    9. XM_011524719.2XP_011523021.1  homeobox protein Hox-B3 isoform X3

      See identical proteins and their annotated locations for XP_011523021.1

      UniProtKB/Swiss-Prot
      P14651
      Conserved Domains (2) summary
      pfam00046
      Location:192244
      Homeobox; Homeobox domain
      pfam13293
      Location:366429
      DUF4074; Domain of unknown function (DUF4074)
    10. XM_011524726.2XP_011523028.1  homeobox protein Hox-B3 isoform X5

      See identical proteins and their annotated locations for XP_011523028.1

      UniProtKB/Swiss-Prot
      P14651
      Related
      ENSP00000419676.1, ENST00000472863.5
      Conserved Domains (2) summary
      pfam00046
      Location:119171
      Homeobox; Homeobox domain
      pfam13293
      Location:293356
      DUF4074; Domain of unknown function (DUF4074)
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