HNRNPL heterogeneous nuclear ribonucleoprotein L [Homo sapiens (human)] - Gene

Summary

Official Symbol: HNRNPLprovided by HGNC
Official Full Name: heterogeneous nuclear ribonucleoprotein Lprovided by HGNC
Primary source: HGNC:HGNC:5045
See related: Ensembl:ENSG00000104824 MIM:603083; AllianceGenome:HGNC:5045
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HNRPL; hnRNP-L; P/OKcl.14
Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 99.2), lymph node (RPKM 60.1) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (38836370..38852347, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (41640403..41656404, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39327010..39342987, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Title: HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
Title: The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
Title: hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
Title: FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
Title: lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
Title: HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
Title: HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
Title: Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
Title: A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein	Gene	Interaction	Pubs
retropepsin	gag-pol	Positional proteomics analysis identifies the cleavage of human heterogeneous nuclear ribonucleoprotein L (HNRNPL) at amino acid residues 392-393 by the HIV-1 protease	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6S1116E (e-PCR)
- UniSTS:151082

MARC_12099-12100:1004643257:1 (e-PCR)
- UniSTS:267338

MARC_12099-12100:1007734785:1 (e-PCR)
- UniSTS:267338

UniSTS:479127 (e-PCR)
- UniSTS:479127

Hnrpl (e-PCR), detects polymorphism
- UniSTS:479127

WI-13808 (e-PCR)
- UniSTS:12190

RH66616 (e-PCR)
- UniSTS:41164

RH70823 (e-PCR)
- UniSTS:88279

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA processing	TAS Traceable Author Statement more info	PubMed
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	EXP Inferred from Experiment more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pronucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed
located_in ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein L

Names: epididymis secretory sperm binding protein; hnRNP L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005335.2 → NP_001005335.1 heterogeneous nuclear ribonucleoprotein L isoform b

See identical proteins and their annotated locations for NP_001005335.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.

Source sequence(s)

AB044547, AC008982, AK094966, AV743120, BC069184, BI256815, BM997815, BQ334900, X16135

Consensus CDS

CCDS33016.1

UniProtKB/TrEMBL

M0QXS5

Related

ENSP00000470231.1, ENST00000600873.5

Conserved Domains (1) summary

TIGR01649
Location:1 → 454

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_001385651.1 → NP_001372580.1 heterogeneous nuclear ribonucleoprotein L isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a retained intron compared to variant 1. The encoded isoform (c) is longer than isoform a

Source sequence(s)

AC008982

UniProtKB/TrEMBL

A0A3B3ITJ4, A0AAG2TNG9

Related

ENSP00000497920.2, ENST00000647557.2

Conserved Domains (1) summary

TIGR01649
Location:100 → 624

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
NM_001533.3 → NP_001524.2 heterogeneous nuclear ribonucleoprotein L isoform a

See identical proteins and their annotated locations for NP_001524.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AB044547, AC008982

Consensus CDS

CCDS33015.1

UniProtKB/Swiss-Prot

A6ND69, A6NIT8, P14866, Q9H3P3

UniProtKB/TrEMBL

M0QXS5

Related

ENSP00000221419.4, ENST00000221419.10

Conserved Domains (1) summary

TIGR01649
Location:100 → 587

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

38836370..38852347 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438739.1 → XP_047294695.1 heterogeneous nuclear ribonucleoprotein L isoform X4
XM_011526888.3 → XP_011525190.1 heterogeneous nuclear ribonucleoprotein L isoform X2

UniProtKB/TrEMBL

A0ACI8ST29, M0QXS5

Related

ENSP00000586414.1, ENST00000916355.1

Conserved Domains (5) summary

cd12699
Location:322 → 395

RRM3_hnRNPL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)

cd12704
Location:438 → 521

RRM4_hnRNPL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)

cd12780
Location:100 → 179

RRM1_hnRNPL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L (hnRNP-L)

TIGR01649
Location:100 → 526

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

cl17169
Location:189 → 227

RRM_SF; RNA recognition motif (RRM) superfamily
XM_047438738.1 → XP_047294694.1 heterogeneous nuclear ribonucleoprotein L isoform X3

UniProtKB/TrEMBL

M0QXS5
XM_047438737.1 → XP_047294693.1 heterogeneous nuclear ribonucleoprotein L isoform X1

UniProtKB/TrEMBL

M0QXS5

Related

ENSP00000469349.1, ENST00000601449.5
XM_047438740.1 → XP_047294696.1 heterogeneous nuclear ribonucleoprotein L isoform X5

Reference GRCh38.p14 PATCHES

Genomic

NW_014040929.1 Reference GRCh38.p14 PATCHES

Range

246042..262019 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331966.1 → XP_054187941.1 heterogeneous nuclear ribonucleoprotein L isoform X4
XM_054331963.1 → XP_054187938.1 heterogeneous nuclear ribonucleoprotein L isoform X2

UniProtKB/TrEMBL

A0ACI8ST29, M0QXS5
XM_054331965.1 → XP_054187940.1 heterogeneous nuclear ribonucleoprotein L isoform X3

UniProtKB/TrEMBL

M0QXS5
XM_054331962.1 → XP_054187937.1 heterogeneous nuclear ribonucleoprotein L isoform X1

UniProtKB/TrEMBL

M0QXS5
XM_054331961.1 → XP_054187936.1 heterogeneous nuclear ribonucleoprotein L isoform X6

UniProtKB/TrEMBL

M0QXS5
XM_054331964.1 → XP_054187939.1 heterogeneous nuclear ribonucleoprotein L isoform X4
XM_054331967.1 → XP_054187942.1 heterogeneous nuclear ribonucleoprotein L isoform X5

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

41640403..41656404 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320805.1 → XP_054176780.1 heterogeneous nuclear ribonucleoprotein L isoform X4
XM_054320802.1 → XP_054176777.1 heterogeneous nuclear ribonucleoprotein L isoform X2

UniProtKB/TrEMBL

A0ACI8ST29, M0QXS5
XM_054320804.1 → XP_054176779.1 heterogeneous nuclear ribonucleoprotein L isoform X3

UniProtKB/TrEMBL

M0QXS5
XM_054320801.1 → XP_054176776.1 heterogeneous nuclear ribonucleoprotein L isoform X1

UniProtKB/TrEMBL

M0QXS5
XM_054320800.1 → XP_054176775.1 heterogeneous nuclear ribonucleoprotein L isoform X7

UniProtKB/TrEMBL

M0QXS5
XM_054320803.1 → XP_054176778.1 heterogeneous nuclear ribonucleoprotein L isoform X4
XM_054320806.1 → XP_054176781.1 heterogeneous nuclear ribonucleoprotein L isoform X5