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    Eea1 early endosome antigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314764, updated on 5-Aug-2018

    Summary

    Official Symbol
    Eea1provided by RGD
    Official Full Name
    early endosome antigen 1provided by RGD
    Primary source
    RGD:1310167
    See related
    Ensembl:ENSRNOG00000021681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Heart (RPKM 206.5), Kidney (RPKM 161.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Eea1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (37101415..37186534)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (37144373..37233282)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546992 Neighboring gene uncharacterized LOC100912143 Neighboring gene 60S ribosomal protein L6-like Neighboring gene pleckstrin homology and RhoGEF domain containing G7 Neighboring gene uncharacterized LOC102549785

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    1-phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
     
    viral RNA genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    viral RNA genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axonal spine IEA
    Inferred from Electronic Annotation
    more info
     
    axonal spine ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-pyruvate aminotransferase complex IEA
    Inferred from Electronic Annotation
    more info
     
    serine-pyruvate aminotransferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108086.2NP_001101556.1  early endosome antigen 1

      See identical proteins and their annotated locations for NP_001101556.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      Related
      ENSRNOP00000029575.4, ENSRNOT00000029764.5
      Conserved Domains (4) summary
      cd15730
      Location:13471409
      FYVE_EEA1; FYVE domain found in early endosome antigen 1 (EEA1) and similar proteins
      pfam01576
      Location:2911340
      Myosin_tail_1; Myosin tail
      pfam07851
      Location:909996
      TMPIT; TMPIT-like protein
      cl19219
      Location:503592
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      37101415..37186534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      27696956..27782232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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