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    Bcl9 BCL9, transcription coactivator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310704, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Bcl9provided by RGD
    Official Full Name
    BCL9, transcription coactivatorprovided by RGD
    Primary source
    RGD:1306934
    See related
    Ensembl:ENSRNOG00000017516 AllianceGenome:RGD:1306934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity. Predicted to be involved in canonical Wnt signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within myotube differentiation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; and somatic stem cell population maintenance. Predicted to be located in cis-Golgi network and nucleus. Predicted to be part of beta-catenin-TCF complex. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 22.2), Kidney (RPKM 19.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (187449425..187475241, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184760616..184846261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199334644..199420083, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RAD9-HUS1-RAD1 interacting nuclear orphan 1, pseudogene 2 Neighboring gene acid phosphatase 6, lysophosphatidic Neighboring gene proline-rich protein 2-like Neighboring gene uncharacterized LOC102549654 Neighboring gene uncharacterized LOC102550046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TMF/ARA160: A key regulator of sperm development. Lerer-Goldshtein T, et al. Dev Biol, 2010 Dec 1. PMID 20691678
    2. Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas. Deka J, et al. Cancer Res, 2010 Aug 15. PMID 20682801
    3. BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Brack AS, et al. Dev Biol, 2009 Nov 1. PMID 19699733, Free PMC Article
    4. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Fritzmann J, et al. Gastroenterology, 2009 Jul. PMID 19328798
    5. Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Adachi S, et al. Cancer Res, 2004 Dec 1. PMID 15574752

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of beta-catenin-TCF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-cell CLL/lymphoma 9 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107703.4 → NP_001101173.2  B-cell CLL/lymphoma 9 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GB32, D4A7D6
      Related
      ENSRNOP00000084827.1, ENSRNOT00000112871.1
      Conserved Domains (2) summary
      PHA03247
      Location:570 → 1160
      PHA03247; large tegument protein UL36; Provisional
      pfam11502
      Location:350 → 388
      BCL9; B-cell lymphoma 9 protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      187449425..187475241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233015.5 → XP_006233077.1  B-cell CLL/lymphoma 9 protein isoform X2

      UniProtKB/TrEMBL
      D4A7D6
      Conserved Domains (2) summary
      pfam04959
      Location:1016 → 1107
      ARS2; Arsenite-resistance protein 2
      pfam11502
      Location:276 → 314
      BCL9; B-cell lymphoma 9 protein

    2. XM_006233014.5 → XP_006233076.1  B-cell CLL/lymphoma 9 protein isoform X1

      UniProtKB/TrEMBL
      D4A7D6
      Conserved Domains (2) summary
      pfam04959
      Location:1078 → 1169
      ARS2; Arsenite-resistance protein 2
      pfam11502
      Location:350 → 388
      BCL9; B-cell lymphoma 9 protein
    Nucleotide Protein Strain
    Heading Accession and Version

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