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    Arsl arylsulfatase L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310326, updated on 18-Jun-2026
    Official Symbol
    Arslprovided by RGD
    Official Full Name
    arylsulfatase Lprovided by RGD
    Primary source
    RGD:1304917
    See related
    Ensembl:ENSRNOG00000028350 AllianceGenome:RGD:1304917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arse
    Summary
    Predicted to enable arylsulfatase activity. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in X-linked chondrodysplasia punctata 1 and chondrodysplasia punctata. Orthologous to several human genes including ARSL (arylsulfatase L). [provided by Alliance of Genome Resources, Apr 2025]
    Expression
    Biased expression in Adrenal (RPKM 63.2), Lung (RPKM 60.3) and 9 other tissues See more
    Try the new Gene page
    Try the new Transcripts and proteins table
    See Arsl in Genome Data Viewer
    Location:
    2q25
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (120966992..120975015)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119038803..119047579)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase family, member 9 Neighboring gene surfeit 6, pseudogene 3 Neighboring gene zinc finger protein 267 Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene POU class 5 homeobox 1, pseudogene 3 Neighboring gene annexin A5

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Related articles in PubMed

    1. X-linked recessive chondrodysplasia punctata due to a new point mutation of the ARSE gene. Parenti G, et al. Am J Med Genet, 1997 Dec 12. PMID 9409863
    2. Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Sardiello M, et al. Hum Mol Genet, 2005 Nov 1. PMID 16174644
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Preferred Names
    arylsulfatase L
    Names
    arylsulfatase E (chondrodysplasia punctata 1)
    NP_001041350.1
    XP_006232343.1
    XP_038958169.1
    XP_038958170.1

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047885.2 → NP_001041350.1  arylsulfatase L precursor

      See identical proteins and their annotated locations for NP_001041350.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6GLK5, Q32KK0
      Conserved Domains (2) summary
      COG3119
      Location:31 → 541
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:34 → 531
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      120966992..120975015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102241.2 → XP_038958169.1  arylsulfatase L isoform X2

      Conserved Domains (1) summary
      cl23718
      Location:34 → 386
      ALP_like; alkaline phosphatases and sulfatases

    2. XM_039102242.2 → XP_038958170.1  arylsulfatase L isoform X3

      UniProtKB/TrEMBL
      B5DEF1
      Conserved Domains (1) summary
      cl23718
      Location:34 → 285
      ALP_like; alkaline phosphatases and sulfatases

    3. XM_006232281.4 → XP_006232343.1  arylsulfatase L isoform X1

      See identical proteins and their annotated locations for XP_006232343.1

      UniProtKB/TrEMBL
      A0A8I6GLK5, Q32KK0
      Related
      ENSRNOP00000096386.1, ENSRNOT00000119901.2
      Conserved Domains (2) summary
      COG3119
      Location:31 → 541
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cl23718
      Location:34 → 531
      ALP_like; alkaline phosphatases and sulfatases

    RNA

    1. XR_005500286.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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