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    Pign phosphatidylinositol glycan anchor biosynthesis, class N [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309051, updated on 8-Apr-2026
    Official Symbol
    Pignprovided by RGD
    Official Full Name
    phosphatidylinositol glycan anchor biosynthesis, class Nprovided by RGD
    Primary source
    RGD:1311346
    See related
    Ensembl:ENSRNOG00000014866 AllianceGenome:RGD:1311346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mannose-ethanolamine phosphotransferase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in cytosol and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 1. Orthologous to human PIGN (phosphatidylinositol glycan anchor biosynthesis class N). [provided by Alliance of Genome Resources, Jul 2025]
    Expression
    Biased expression in Kidney (RPKM 212.7), Liver (RPKM 179.5) and 9 other tissues See more
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See Pign in Genome Data Viewer
    Location:
    13p11
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (22173670..22321344, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (21659092..21812932, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (25510593..25662943, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481471 Neighboring gene FAU ubiquitin like and ribosomal protein S30 fusion, pseudogene 3 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing Neighboring gene transfer RNA histidine (anticodon AUG) 1

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mannose-ethanolamine phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-ethanolamine phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    GPI ethanolamine phosphate transferase 1
    Names
    phosphatidylinositol glycan, class N

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100584.2 → NP_001094054.2  GPI ethanolamine phosphate transferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JST6
      Related
      ENSRNOP00000101147.1, ENSRNOT00000164181.1

    2. NM_001429600.1 → NP_001416529.1  GPI ethanolamine phosphate transferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JST6

    3. NM_001429601.1 → NP_001416530.1  GPI ethanolamine phosphate transferase 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JST6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      22173670..22321344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272414.1 → XP_063128484.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    2. XM_063272411.1 → XP_063128481.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    3. XM_039090846.2 → XP_038946774.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6
      Conserved Domains (2) summary
      cd16020
      Location:40 → 345
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
      pfam04987
      Location:431 → 884
      PigN; Phosphatidylinositolglycan class N (PIG-N)

    4. XM_063272410.1 → XP_063128480.1  GPI ethanolamine phosphate transferase 1 isoform X1

    5. XM_063272415.1 → XP_063128485.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    6. XM_063272409.1 → XP_063128479.1  GPI ethanolamine phosphate transferase 1 isoform X1

    7. XM_063272416.1 → XP_063128486.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    8. XM_063272413.1 → XP_063128483.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    9. XM_063272412.1 → XP_063128482.1  GPI ethanolamine phosphate transferase 1 isoform X1

      UniProtKB/TrEMBL
      A6JST6

    10. XM_063272417.1 → XP_063128487.1  GPI ethanolamine phosphate transferase 1 isoform X3

    11. XM_063272419.1 → XP_063128489.1  GPI ethanolamine phosphate transferase 1 isoform X5

    12. XM_039090847.2 → XP_038946775.1  GPI ethanolamine phosphate transferase 1 isoform X2

      UniProtKB/TrEMBL
      A0ABK0LG47, A0ABK0LNZ1
      Related
      ENSRNOP00000104668.1, ENSRNOT00000122872.1
      Conserved Domains (2) summary
      cd16020
      Location:40 → 345
      GPI_EPT_1; GPI ethanolamine phosphate transferase 1; PIG-N
      pfam04987
      Location:431 → 884
      PigN; Phosphatidylinositolglycan class N (PIG-N)

    13. XM_063272418.1 → XP_063128488.1  GPI ethanolamine phosphate transferase 1 isoform X4

    RNA

    1. XR_010056922.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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