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    Ank1 ankyrin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306570, updated on 10-Jul-2024

    Summary

    Official Symbol
    Ank1provided by RGD
    Official Full Name
    ankyrin 1provided by RGD
    Primary source
    RGD:1309620
    See related
    EnsemblRapid:ENSRNOG00000018241 AllianceGenome:RGD:1309620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Involved in positive regulation of organelle organization. Located in several cellular components, including axolemma; sarcolemma; and sarcomere. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 210.6), Muscle (RPKM 101.7) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ank1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75578824..75757464, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (68876294..69054963, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (73681422..73912605, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 4 Neighboring gene NK6 homeobox 3 Neighboring gene uncharacterized LOC120097525 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1-like Neighboring gene lysine acetyltransferase 6A Neighboring gene uncharacterized LOC134482522 Neighboring gene uncharacterized LOC120097527

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal anchor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables spectrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ankyrin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spectrin-associated cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ankyrin-1
    Names
    ankyrin 1, erythrocytic
    ankyrin 1, erythroid

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395562.1NP_001382491.1  ankyrin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZJ94
      Related
      ENSRNOP00000110762.1, ENSRNOT00000126003.1
      Conserved Domains (9) summary
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:415625
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:123468
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14421525
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:700731
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:767819
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12771406
      UPA_2; UPA domain
      pfam12796
      Location:49140
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:579792
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001395563.1NP_001382492.1  ankyrin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6A0H1
      Related
      ENSRNOP00000084044.1, ENSRNOT00000094764.2
      Conserved Domains (9) summary
      smart00218
      Location:9071011
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:378588
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:86431
      PHA02876; ankyrin repeat protein; Provisional
      COG0666
      Location:5163
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08805
      Location:13971480
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:663694
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:730782
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12321361
      UPA_2; UPA domain
      cl39094
      Location:542755
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001395564.1NP_001382493.1  ankyrin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZS64
      Related
      ENSRNOP00000081687.2, ENSRNOT00000094734.2
      Conserved Domains (9) summary
      smart00218
      Location:9231027
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:386596
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:94439
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14131496
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:671702
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:738790
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12481377
      UPA_2; UPA domain
      pfam12796
      Location:20111
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:550763
      Ank_2; Ankyrin repeats (3 copies)
    4. NM_001395565.1NP_001382494.1  ankyrin-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Conserved Domains (9) summary
      smart00218
      Location:9071011
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:378588
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:86431
      PHA02876; ankyrin repeat protein; Provisional
      COG0666
      Location:5163
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd08805
      Location:13971480
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:663694
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:730782
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12321361
      UPA_2; UPA domain
      cl39094
      Location:542755
      Ank_2; Ankyrin repeats (3 copies)
    5. NM_001395566.1NP_001382495.1  ankyrin-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6ABK4
      Conserved Domains (9) summary
      smart00218
      Location:9231027
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:386596
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:94439
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14131496
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:671702
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:738790
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12481377
      UPA_2; UPA domain
      pfam12796
      Location:20111
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:550763
      Ank_2; Ankyrin repeats (3 copies)
    6. NM_001395567.1NP_001382496.1  ankyrin-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Related
      ENSRNOP00000062056.3, ENSRNOT00000064070.4
      Conserved Domains (9) summary
      smart00218
      Location:9231027
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:386596
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:94439
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14131496
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:671702
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:738790
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12481377
      UPA_2; UPA domain
      pfam12796
      Location:20111
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:550763
      Ank_2; Ankyrin repeats (3 copies)
    7. NM_001395568.1NP_001382497.1  ankyrin-1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      Conserved Domains (9) summary
      smart00218
      Location:9441048
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:415625
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:123468
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14341517
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:700731
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:767819
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12691398
      UPA_2; UPA domain
      pfam12796
      Location:49140
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:579792
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      75578824..75757464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094577.2XP_038950505.1  ankyrin-1 isoform X15

      Related
      ENSRNOP00000076708.2, ENSRNOT00000102914.2
      Conserved Domains (9) summary
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:415625
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:123468
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14421525
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:700731
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:767819
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12771406
      UPA_2; UPA domain
      pfam12796
      Location:49140
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:579792
      Ank_2; Ankyrin repeats (3 copies)
    2. XM_039094571.2XP_038950499.1  ankyrin-1 isoform X7

      Conserved Domains (9) summary
      smart00218
      Location:9521056
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:415625
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:123468
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14421525
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:700731
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:767819
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12771406
      UPA_2; UPA domain
      pfam12796
      Location:49140
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:579792
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_039094582.2XP_038950510.2  ankyrin-1 isoform X20

    4. XM_063275451.1XP_063131521.1  ankyrin-1 isoform X16

    5. XM_063275448.1XP_063131518.1  ankyrin-1 isoform X11

    6. XM_039094574.2XP_038950502.2  ankyrin-1 isoform X10

    7. XM_039094569.2XP_038950497.2  ankyrin-1 isoform X6

    8. XM_039094581.2XP_038950509.2  ankyrin-1 isoform X19

    9. XM_039094568.2XP_038950496.2  ankyrin-1 isoform X5

    10. XM_063275450.1XP_063131520.1  ankyrin-1 isoform X14

    11. XM_039094566.2XP_038950494.2  ankyrin-1 isoform X4

    12. XM_039094572.2XP_038950500.2  ankyrin-1 isoform X8

    13. XM_039094565.2XP_038950493.2  ankyrin-1 isoform X3

    14. XM_039094564.2XP_038950492.2  ankyrin-1 isoform X2

    15. XM_039094562.2XP_038950490.2  ankyrin-1 isoform X1

    16. XM_063275453.1XP_063131523.1  ankyrin-1 isoform X18

    17. XM_063275452.1XP_063131522.1  ankyrin-1 isoform X17

      UniProtKB/TrEMBL
      A0A8I6GAS7
    18. XM_063275449.1XP_063131519.1  ankyrin-1 isoform X13

      Related
      ENSRNOP00000083447.2, ENSRNOT00000094015.2
    19. XM_039094576.2XP_038950504.1  ankyrin-1 isoform X12

      Conserved Domains (9) summary
      smart00218
      Location:9231027
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02875
      Location:386596
      PHA02875; ankyrin repeat protein; Provisional
      PHA02876
      Location:94439
      PHA02876; ankyrin repeat protein; Provisional
      cd08805
      Location:14131496
      Death_ank1; Death domain of Ankyrin-1
      sd00045
      Location:671702
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:738790
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12481377
      UPA_2; UPA domain
      pfam12796
      Location:20111
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:550763
      Ank_2; Ankyrin repeats (3 copies)
    20. XM_063275454.1XP_063131524.1  ankyrin-1 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZQ60
      Related
      ENSRNOP00000080599.1, ENSRNOT00000114184.2
    21. XM_039094585.2XP_038950513.1  ankyrin-1 isoform X23

    22. XM_039094584.2XP_038950512.1  ankyrin-1 isoform X22

    23. XM_063275447.1XP_063131517.1  ankyrin-1 isoform X9

    RNA

    1. XR_005494624.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107322.2: Suppressed sequence

      Description
      NM_001107322.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.