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    Usp22 ubiquitin specific peptidase 22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303201, updated on 21-Jul-2018

    Summary

    Official Symbol
    Usp22provided by RGD
    Official Full Name
    ubiquitin specific peptidase 22provided by RGD
    Primary source
    RGD:1310354
    See related
    Ensembl:ENSRNOG00000032492
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Brain (RPKM 493.1), Adrenal (RPKM 237.7) and 9 other tissues See more
    Orthologs

    Genomic context

    See Usp22 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47429201..47453298, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (47203849..47227946, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene SRA stem-loop-interacting RNA-binding protein, mitochondrial pseudogene Neighboring gene TNF receptor superfamily member 13B Neighboring gene aldehyde dehydrogenase 3 family, member A1 Neighboring gene similar to Related RAS viral (r-ras) oncogene homolog 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    H4 histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to H4 histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    nuclear receptor transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitin-specific protease activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    histone H4 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    histone ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SAGA complex IEA
    Inferred from Electronic Annotation
    more info
     
    SAGA complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with SAGA-type complex ISO
    Inferred from Sequence Orthology
    more info
     
    cellular_component ND
    No biological Data available
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 22
    Names
    ubiquitin specific protease 22
    NP_001178573.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191644.1NP_001178573.1  ubiquitin carboxyl-terminal hydrolase 22

      Status: PROVISIONAL

      Source sequence(s)
      AC118419
      UniProtKB/TrEMBL
      D3ZTX7
      Related
      ENSRNOP00000044118.3, ENSRNOT00000050061.5
      Conserved Domains (3) summary
      cd02660
      Location:176518
      Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:175517
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:63123
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      47429201..47453298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      45085173..45109272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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