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    Robo4 roundabout guidance receptor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300518, updated on 18-Apr-2019

    Summary

    Official Symbol
    Robo4provided by RGD
    Official Full Name
    roundabout guidance receptor 4provided by RGD
    Primary source
    RGD:727947
    See related
    Ensembl:ENSRNOG00000049289
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Annotation information
    Note: GeneIDs: 100911068 and 300518 are annotated independently on Rnor_6.0 (Annotation Release 105) but may be redundant loci. [24 Feb 2015]
    Expression
    Biased expression in Heart (RPKM 63.4), Lung (RPKM 45.2) and 9 other tissues See more

    Genomic context

    See Robo4 in Genome Data Viewer
    Location:
    8q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39082693..39093344, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (39089746..39099696, complement)

    Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351673 Neighboring gene uncharacterized LOC108348206 Neighboring gene similar to heat shock protein 1, beta Neighboring gene acrosomal vesicle protein 1 Neighboring gene checkpoint kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    roundabout homolog 4
    Names
    Magic roundabout
    roundabout, axon guidance receptor, homolog 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181375.1NP_852040.1  roundabout homolog 4 precursor

      See identical proteins and their annotated locations for NP_852040.1

      Status: PROVISIONAL

      Source sequence(s)
      AY277635
      UniProtKB/Swiss-Prot
      Q80W87
      Related
      ENSRNOP00000044365.3, ENSRNOT00000043344.3
      Conserved Domains (3) summary
      pfam07679
      Location:150231
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:361443
      fn3; Fibronectin type III domain
      cl11960
      Location:152236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

      Range
      39082693..39093344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766051.2XP_008764273.1  roundabout homolog 4 isoform X1

      Conserved Domains (3) summary
      pfam07679
      Location:150231
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:361443
      fn3; Fibronectin type III domain
      cl11960
      Location:152236
      Ig; Immunoglobulin domain

    Alternate Rn_Celera

    Genomic

    1. AC_000076.1 Alternate Rn_Celera

      Range
      37322941..37332891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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