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    NRBP1 nuclear receptor binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 29959, updated on 17-Jun-2024

    Summary

    Official Symbol
    NRBP1provided by HGNC
    Official Full Name
    nuclear receptor binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:7993
    See related
    Ensembl:ENSG00000115216 MIM:606010; AllianceGenome:HGNC:7993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MADM; NRBP; BCON3; MUDPNP
    Summary
    Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NRBP1 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27427790..27442259)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27470161..27484612)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27650657..27665126)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27601343-27602213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11297 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27618171-27618672 Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor binding protein 1 (NRBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NRBP1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ27109, FLJ35541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nuclear receptor-binding protein
    Names
    multiple domain putative nuclear protein
    myeloid leukemia factor 1 adaptor molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321357.2NP_001308286.1  nuclear receptor-binding protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074117, AK122664, BC001221
      Consensus CDS
      CCDS1753.1
      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31
      Related
      ENSP00000233557.3, ENST00000233557.7
      Conserved Domains (1) summary
      cd14034
      Location:60334
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    2. NM_001321358.2NP_001308287.1  nuclear receptor-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      Consensus CDS
      CCDS82433.1
      UniProtKB/TrEMBL
      B4DW31, F8W6G1
      Conserved Domains (1) summary
      cd14034
      Location:60342
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    3. NM_001321359.2NP_001308288.1  nuclear receptor-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      Consensus CDS
      CCDS82433.1
      UniProtKB/TrEMBL
      B4DW31, F8W6G1
      Related
      ENSP00000369192.3, ENST00000379863.7
      Conserved Domains (1) summary
      cd14034
      Location:60342
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    4. NM_001321361.2NP_001308290.1  nuclear receptor-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (2) summary
      smart00220
      Location:83332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14034
      Location:60341
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    5. NM_001321362.2NP_001308291.1  nuclear receptor-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (1) summary
      cd14034
      Location:60333
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1
    6. NM_001321363.2NP_001308292.1  nuclear receptor-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (1) summary
      cl21453
      Location:60302
      PKc_like; Protein Kinases, catalytic domain
    7. NM_013392.4NP_037524.1  nuclear receptor-binding protein isoform 1

      See identical proteins and their annotated locations for NP_037524.1

      Status: VALIDATED

      Source sequence(s)
      BC001221, BQ949042
      Consensus CDS
      CCDS1753.1
      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31
      Related
      ENSP00000369181.3, ENST00000379852.8
      Conserved Domains (1) summary
      cd14034
      Location:60334
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27427790..27442259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444036.1XP_047299992.1  nuclear receptor-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27470161..27484612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341567.1XP_054197542.1  nuclear receptor-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31