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    OSGIN1 oxidative stress induced growth inhibitor 1 [ Homo sapiens (human) ]

    Gene ID: 29948, updated on 8-Jul-2021

    Summary

    Official Symbol
    OSGIN1provided by HGNC
    Official Full Name
    oxidative stress induced growth inhibitor 1provided by HGNC
    Primary source
    HGNC:HGNC:30093
    See related
    Ensembl:ENSG00000140961 MIM:607975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BDGI; OKL38
    Summary
    This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues See more
    Orthologs
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    Genomic context

    See OSGIN1 in Genome Data Viewer
    Location:
    16q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (83953240..83966332)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (83986845..83999937)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371372 Neighboring gene uncharacterized LOC105371371 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene solute carrier family 38 member 8 Neighboring gene RNA, 5S ribosomal pseudogene 432

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: MLYCD

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    oxidative stress-induced growth inhibitor 1
    Names
    BMSC-derived growth inhibitor
    bone marrow stromal cell-derived growth inhibitor
    ovary, kidney and liver protein 38
    pregnancy-induced growth inhibitor OKL38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029757.1 RefSeqGene

      Range
      5019..18111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_182981.3NP_892026.1  oxidative stress-induced growth inhibitor 1

      See identical proteins and their annotated locations for NP_892026.1

      Status: REVIEWED

      Source sequence(s)
      AC040169, AY258068, BM976366
      Consensus CDS
      CCDS10939.1
      UniProtKB/Swiss-Prot
      Q9UJX0
      Related
      ENSP00000376983.1, ENST00000393306.6
      Conserved Domains (1) summary
      TIGR04018
      Location:177471
      Bthiol_YpdA; putative bacillithiol system oxidoreductase, YpdA family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      83953240..83966332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_013370.3: Suppressed sequence

      Description
      NM_013370.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein, and the transcript appears to retain an intron at its 5' end.
    2. NM_182980.2: Suppressed sequence

      Description
      NM_182980.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which appears to retain an intron at its 5' end.
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