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    CNOT7 CCR4-NOT transcription complex subunit 7 [ Homo sapiens (human) ]

    Gene ID: 29883, updated on 15-Jun-2019

    Summary

    Official Symbol
    CNOT7provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 7provided by HGNC
    Primary source
    HGNC:HGNC:14101
    See related
    Ensembl:ENSG00000198791 MIM:604913
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAF1; CAF-1; Caf1a; hCAF-1
    Summary
    The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 13.0), lymph node (RPKM 9.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See CNOT7 in Genome Data Viewer
    Location:
    8p22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (17221981..17246909, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17086737..17104387, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene zinc finger DHHC-type containing 2 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene myotubularin related protein 7 Neighboring gene uncharacterized LOC102724838 Neighboring gene ADAM metallopeptidase domain 24, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Deadenylation of mRNA, organism-specific biosystem (from REACTOME)
      Deadenylation of mRNA, organism-specific biosystemDeadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 compl...
    • Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
      Deadenylation-dependent mRNA decay, organism-specific biosystemAfter undergoing rounds of translation, mRNA is normally destroyed by the deadenylation-dependent pathway. Though the trigger is unclear, deadenylation likely proceeds in two steps: one catalyzed by...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Transcription of Cell Cycle Genes, organism-specific biosystemUnder a variety of stress conditions, TP53 (p53), stabilized by stress-induced phosphorylation at least on S15 and S20 serine residues, can induce the transcription of genes involved in cell cycle ar...
    • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystem (from REACTOME)
      TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, organism-specific biosystemBTG2 is induced by TP53, leading to cessation of cellular proliferation (Rouault et al. 1996, Duriez et al. 2002). BTG2 binds to the CCR4-NOT complex and promotes mRNA deadenylation activity of this ...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    3'-5'-exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    RNA phosphodiester bond hydrolysis, exonucleolytic IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic mRNA processing body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gene silencing by RNA ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    gene silencing by miRNA TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear-transcribed mRNA poly(A) tail shortening TAS
    Traceable Author Statement
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    CCR4-NOT complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    host cell PML body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane HDA PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 7
    Names
    BTG1-binding factor 1
    CCR4-associated factor 1
    carbon catabolite repressor protein (CCR4)-associative factor 1
    NP_001309016.1
    NP_001309017.1
    NP_001309018.1
    NP_001309019.1
    NP_001309020.1
    NP_001309021.1
    NP_001309022.1
    NP_001309023.1
    NP_001309024.1
    NP_001309025.1
    NP_001309026.1
    NP_001309027.1
    NP_001309028.1
    NP_001309029.1
    NP_037486.2
    NP_473367.2
    XP_005273538.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322087.1NP_001309016.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AW448990, BC070187, BI094365, BI458088, DA695885, DA752620
      Consensus CDS
      CCDS55202.1
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:1244
      CAF1; CAF1 family ribonuclease
    2. NM_001322088.1NP_001309017.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AL833642, AW448990, BC070187, BI094365, BI552176, DA695885
      Consensus CDS
      CCDS55202.1
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:1244
      CAF1; CAF1 family ribonuclease
    3. NM_001322089.1NP_001309018.1  CCR4-NOT transcription complex subunit 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, and contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AC091050, AW448990, BC070187, BI094365, BI464507, DA695885, HY002876
      Consensus CDS
      CCDS55202.1
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:1244
      CAF1; CAF1 family ribonuclease
    4. NM_001322090.2NP_001309019.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, BI458088, DA752620
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    5. NM_001322091.2NP_001309020.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    6. NM_001322092.2NP_001309021.1  CCR4-NOT transcription complex subunit 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187, BI458088
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    7. NM_001322093.2NP_001309022.1  CCR4-NOT transcription complex subunit 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is longer than isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, BI464507, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1301
      CAF1; CAF1 family ribonuclease
    8. NM_001322094.2NP_001309023.1  CCR4-NOT transcription complex subunit 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate splice site in the 3' terminal exon and thus contains an alternate 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AL528251, BC007315, BC070187, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:1245
      CAF1; CAF1 family ribonuclease
    9. NM_001322095.2NP_001309024.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA508565, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2198
      CAF1; CAF1 family ribonuclease
    10. NM_001322096.2NP_001309025.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) contains an additional exon and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA720240, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2198
      CAF1; CAF1 family ribonuclease
    11. NM_001322097.2NP_001309026.1  CCR4-NOT transcription complex subunit 7 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) contains alternate 5' exon structure and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (5) is shorter at the N-terminus, compared to isoform 1. Variants 11, 12 and 13 all encode isoform 5.
      Source sequence(s)
      AC091050, AL833642, BC007315, BC070187, DA720240
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Conserved Domains (1) summary
      cl23804
      Location:2198
      CAF1; CAF1 family ribonuclease
    12. NM_001322098.1NP_001309027.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA508565, DA695885, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2163
      CAF1; CAF1 family ribonuclease
    13. NM_001322099.1NP_001309028.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) contains an additional exon and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA695885, DA720240, DA752620
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2163
      CAF1; CAF1 family ribonuclease
    14. NM_001322100.1NP_001309029.1  CCR4-NOT transcription complex subunit 7 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, and it also contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform 1. Variants 14, 15 and 16 all encode isoform 6.
      Source sequence(s)
      AW448990, BC070187, BI094365, BI458088, BI552176, DA508565, DA695885
      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:2163
      CAF1; CAF1 family ribonuclease
    15. NM_013354.7NP_037486.2  CCR4-NOT transcription complex subunit 7 isoform 1

      See identical proteins and their annotated locations for NP_037486.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 6, 7 and 8 all encode isoform 1.
      Source sequence(s)
      AC091050, BC007315, BC070187, DA752620
      Consensus CDS
      CCDS6000.2
      UniProtKB/Swiss-Prot
      Q9UIV1
      UniProtKB/TrEMBL
      Q96IQ6
      Related
      ENSP00000355279.4, ENST00000361272.9
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
    16. NM_054026.3NP_473367.2  CCR4-NOT transcription complex subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_473367.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 all encode isoform 2.
      Source sequence(s)
      AW448990, BC070187, BI094365, DA695885, DA752620
      Consensus CDS
      CCDS55202.1
      UniProtKB/Swiss-Prot
      Q9UIV1
      Related
      ENSP00000429093.1, ENST00000523917.5
      Conserved Domains (1) summary
      cl23804
      Location:1244
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      17221981..17246909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273481.3XP_005273538.1  CCR4-NOT transcription complex subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_005273538.1

      UniProtKB/Swiss-Prot
      Q9UIV1
      Conserved Domains (1) summary
      cl23804
      Location:1279
      CAF1; CAF1 family ribonuclease
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