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    ZDHHC8 zinc finger DHHC-type containing 8 [ Homo sapiens (human) ]

    Gene ID: 29801, updated on 15-Jun-2019

    Summary

    Official Symbol
    ZDHHC8provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 8provided by HGNC
    Primary source
    HGNC:HGNC:18474
    See related
    Ensembl:ENSG00000099904 MIM:608784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC8; ZNF378; ZDHHCL1
    Summary
    This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
    Expression
    Ubiquitous expression in fat (RPKM 6.8), spleen (RPKM 6.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZDHHC8 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (20131841..20148007)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20119364..20135530)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene microRNA 6816 Neighboring gene RAN binding protein 1 Neighboring gene small nucleolar RNA, H/ACA box 77B Neighboring gene coiled-coil domain containing 188 Neighboring gene enhancer-blocking element 22-3 upstream of CCDC188

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • HDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
      HDL-mediated lipid transport, organism-specific biosystemHDL particles play a central role in the reverse transport of cholesterol, the process by which cholesterol in tissues other than the liver is returned to the liver for conversion to bile salts and e...
    • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
      Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
    • Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
      Lipoprotein metabolism, organism-specific biosystemBecause of their hydrophobicity, lipids are found in the extracellular spaces of the human body primarily in the form of lipoprotein complexes. Chylomicrons form in the small intestine and transport ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-cysteine S-palmitoyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    high-density lipoprotein particle assembly TAS
    Traceable Author Statement
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    protein palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    probable palmitoyltransferase ZDHHC8
    Names
    membrane-associated DHHC8 zinc finger protein
    zinc finger protein 378
    zinc finger, DHHC domain like containing 1
    NP_001171953.1
    NP_037505.1
    XP_006724302.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021420.1 RefSeqGene

      Range
      5001..21167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001185024.2NP_001171953.1  probable palmitoyltransferase ZDHHC8 isoform 1

      See identical proteins and their annotated locations for NP_001171953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC006547, AK131238, AY894890
      Consensus CDS
      CCDS54502.1
      UniProtKB/Swiss-Prot
      Q9ULC8
      Related
      ENSP00000384716.3, ENST00000405930.3
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase
    2. NM_013373.4NP_037505.1  probable palmitoyltransferase ZDHHC8 isoform 2

      See identical proteins and their annotated locations for NP_037505.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC006547, AY894890, BC053544
      Consensus CDS
      CCDS13776.1
      UniProtKB/Swiss-Prot
      Q9ULC8
      Related
      ENSP00000334490.7, ENST00000334554.11
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      20131804..20148007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724239.2XP_006724302.1  probable palmitoyltransferase ZDHHC8 isoform X1

      See identical proteins and their annotated locations for XP_006724302.1

      UniProtKB/Swiss-Prot
      Q9ULC8
      Conserved Domains (1) summary
      pfam01529
      Location:99224
      zf-DHHC; DHHC palmitoyltransferase
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