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    Ddrgk1 DDRGK domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296162, updated on 19-Apr-2019

    Summary

    Official Symbol
    Ddrgk1provided by RGD
    Official Full Name
    DDRGK domain containing 1provided by RGD
    Primary source
    RGD:1309979
    See related
    Ensembl:ENSRNOG00000021232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309979
    Expression
    Biased expression in Adrenal (RPKM 197.5), Kidney (RPKM 186.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Ddrgk1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123195580..123206828, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (129693708..129704956, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene inosine triphosphatase Neighboring gene solute carrier family 4 member 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    RNA polymerase II repressing transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin-like protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of I-kappaB phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of protein localization to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein K69-linked ufmylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein K69-linked ufmylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    NOT regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDRGK domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106512.1NP_001099982.1  DDRGK domain-containing protein 1

      See identical proteins and their annotated locations for NP_001099982.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      D3ZAS9
      Related
      ENSRNOP00000036810.4, ENSRNOT00000030192.4
      Conserved Domains (1) summary
      pfam09756
      Location:140328
      DDRGK; DDRGK domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      123195580..123206828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      116682282..116693534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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