Format

Send to:

Choose Destination
    • Showing Current items.

    GTF2E2 general transcription factor IIE subunit 2 [ Homo sapiens (human) ]

    Gene ID: 2961, updated on 17-Jun-2019

    Summary

    Official Symbol
    GTF2E2provided by HGNC
    Official Full Name
    general transcription factor IIE subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:4651
    See related
    Ensembl:ENSG00000197265 MIM:189964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FE; TTD6; TF2E2; TFIIE-B
    Summary
    The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]
    Expression
    Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 9.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See GTF2E2 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (30578318..30658241, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30436031..30515738, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene Sharpr-MPRA regulatory region 2547 Neighboring gene uncharacterized LOC112268024 Neighboring gene RNA, U5A small nuclear 3, pseudogene Neighboring gene small integral membrane protein 18 Neighboring gene glutathione-disulfide reductase Neighboring gene uncharacterized LOC105379356 Neighboring gene uncharacterized LOC105379355 Neighboring gene UBX domain protein 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Trichothiodystrophy 6, nonphotosensitive
    MedGen: C4310785 OMIM: 616943 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Common genetic variation and performance on standardized cognitive tests.
    NHGRI GWA Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of general transcription factor IIE, polypeptide 2, beta 34kDa (GTF2E2; TFIIE-B) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme and transcription preinitiation complexes, which include TFIIE, during Tat-mediated transactivation of the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to TFIIH-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    snRNA transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    transcription initiation from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription initiation factor IIE subunit beta
    Names
    TFIIE beta subunit
    TFIIE-beta
    general transcription factor IIE, polypeptide 2, beta 34kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052833.1 RefSeqGene

      Range
      5001..84924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348353.1NP_001335282.1  transcription initiation factor IIE subunit beta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC102945, AC103959
      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    2. NM_002095.6NP_002086.1  transcription initiation factor IIE subunit beta isoform 1

      See identical proteins and their annotated locations for NP_002086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA483281, BC030572, BX421791
      Consensus CDS
      CCDS6078.1
      UniProtKB/Swiss-Prot
      P29084
      Related
      ENSP00000348168.4, ENST00000355904.9
      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      30578318..30658241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017013364.1XP_016868853.1  transcription initiation factor IIE subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P29084
      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    2. XM_017013363.1XP_016868852.1  transcription initiation factor IIE subunit beta isoform X1

      UniProtKB/Swiss-Prot
      P29084
      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    3. XM_024447138.1XP_024302906.1  transcription initiation factor IIE subunit beta isoform X1

      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    4. XM_011544509.2XP_011542811.1  transcription initiation factor IIE subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011542811.1

      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    5. XM_011544510.1XP_011542812.1  transcription initiation factor IIE subunit beta isoform X3

      Related
      ENSP00000429921.1, ENST00000518599.5
      Conserved Domains (1) summary
      cd07977
      Location:68146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    Support Center