U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Amhr2 anti-Mullerian hormone receptor type 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29530, updated on 13-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Amhr2provided by RGD
    Official Full Name
    anti-Mullerian hormone receptor type 2provided by RGD
    Primary source
    RGD:70964
    See related
    Ensembl:ENSRNOG00000014850 AllianceGenome:RGD:70964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C14; MRII; MISRII
    Summary
    Enables transforming growth factor beta receptor activity, type II. Involved in female gonad development and male gonad development. Acts upstream of or within transforming growth factor beta receptor signaling pathway. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in persistent Mullerian duct syndrome. Orthologous to human AMHR2 (anti-Mullerian hormone receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 106.1), Heart (RPKM 38.7) and 6 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    7q36
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135454517..135470183)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133579152..133588874)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144052202..144060678)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Sp7 transcription factor Neighboring gene Sp1 transcription factor Neighboring gene uncharacterized LOC134479584 Neighboring gene proline rich 13 Neighboring gene poly(rC) binding protein 2 Neighboring gene mitogen activated protein kinase kinase kinase 12

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity. Mendis-Handagama SM, et al. Histol Histopathol, 2006 Feb. PMID 16329036
    2. Transcriptional regulation of the rat Müllerian inhibiting substance type II receptor in rodent Leydig cells. Teixeira J, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570158, Free PMC Article
    3. Developmental expression of a candidate müllerian inhibiting substance type II receptor. Teixeira J, et al. Endocrinology, 1996 Jan. PMID 8536608
    4. A novel member of the transmembrane serine/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the müllerian duct. Baarends WM, et al. Development, 1994 Jan. PMID 8119126
    5. The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. Imhoff FM, et al. FEBS Lett, 2013 Jun 19. PMID 23624077

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. physiological function(s) of type 2 anti-Mullerian hormone receptor
      Title: The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors.
    2. Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MISRI receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression.
      Title: Müllerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in Müllerian duct regression.
    3. examined the presence of AMH receptor type II (AMHR-II) in fetal Leydig cells (FLC) and cells in the adult Leydig cells lineage in the postnatal testis; presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC
      Title: Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anti-Mullerian hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anti-Mullerian hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hormone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transforming growth factor beta receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor activity, type II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transforming growth factor beta receptor activity, type II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anti-Mullerian hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anti-Mullerian hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anti-Mullerian hormone receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in blood vessel development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of anti-Mullerian hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sex differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sex differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    anti-Muellerian hormone type-2 receptor
    Names
    AMH type II receptor
    MIS type II receptor
    anti-Muellerian hormone type II receptor
    anti-Mullerian hormone receptor type 11 SV1
    anti-Mullerian hormone receptor, type II
    anti-Mullerian hormone type 2 receptor
    NP_112260.1
    XP_038934520.1
    XP_038934521.1
    XP_038934523.1
    XP_038934524.1
    XP_063119188.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030998.2 → NP_112260.1  anti-Muellerian hormone type-2 receptor precursor

      See identical proteins and their annotated locations for NP_112260.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q62893, Q63045, Q9R0A7
      UniProtKB/TrEMBL
      A6KCV2
      Related
      ENSRNOP00000020103.4, ENSRNOT00000020103.6
      Conserved Domains (2) summary
      pfam01064
      Location:61 → 119
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:205 → 506
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135454517..135470183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078593.2 → XP_038934521.1  anti-Muellerian hormone type-2 receptor isoform X1

      UniProtKB/Swiss-Prot
      Q62893, Q63045, Q9R0A7
      UniProtKB/TrEMBL
      A6KCV2
      Conserved Domains (2) summary
      pfam01064
      Location:61 → 119
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:205 → 506
      PKc_like; Protein Kinases, catalytic domain

    2. XM_063263118.1 → XP_063119188.1  anti-Muellerian hormone type-2 receptor isoform X2

    3. XM_039078592.2 → XP_038934520.1  anti-Muellerian hormone type-2 receptor isoform X1

      UniProtKB/Swiss-Prot
      Q62893, Q63045, Q9R0A7
      UniProtKB/TrEMBL
      A6KCV2
      Conserved Domains (2) summary
      pfam01064
      Location:61 → 119
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:205 → 506
      PKc_like; Protein Kinases, catalytic domain

    4. XM_039078596.2 → XP_038934524.1  anti-Muellerian hormone type-2 receptor isoform X3

      UniProtKB/TrEMBL
      A0A088DKH8, A6KCV3
      Related
      ENSRNOP00000069243.1
      Conserved Domains (2) summary
      pfam01064
      Location:61 → 119
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:205 → 428
      PKc_like; Protein Kinases, catalytic domain

    5. XM_039078595.2 → XP_038934523.1  anti-Muellerian hormone type-2 receptor isoform X2

      Conserved Domains (2) summary
      pfam01064
      Location:61 → 119
      Activin_recp; Activin types I and II receptor domain
      cl21453
      Location:206 → 429
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62893.1 GenPept UniProtKB/Swiss-Prot:Q62893

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous