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    Swap70 switching B-cell complex subunit SWAP70 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293410, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Swap70provided by RGD
    Official Full Name
    switching B-cell complex subunit SWAP70provided by RGD
    Primary source
    RGD:1305579
    See related
    Ensembl:ENSRNOG00000009910 AllianceGenome:RGD:1305579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and DNA binding activity. Predicted to be involved in several processes, including negative regulation of cell-cell adhesion mediated by integrin; negative regulation of peptidyl-serine dephosphorylation; and regulation of actin filament organization. Predicted to act upstream of or within isotype switching. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be active in cytoplasm and nucleus. Orthologous to human SWAP70 (switching B cell complex subunit SWAP70). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Spleen (RPKM 403.2), Kidney (RPKM 129.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (173702338..173763540)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (164267588..164328796)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (174862683..174924101)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483773 Neighboring gene zinc finger protein 143 Neighboring gene RNA, U6 small nuclear 1168 Neighboring gene WEE1 G2 checkpoint kinase Neighboring gene SET binding factor 2 Neighboring gene N-lysine methyltransferase KMT5A-like Neighboring gene Y box binding protein 1, pseudogene 18 Neighboring gene lysine methyltransferase 5A, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration. Sivalenka RR, et al. Mol Cell Biol, 2004 Dec. PMID 15542837, Free PMC Article
    2. The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. Chacón-Martínez CA, et al. J Biol Chem, 2013 Oct 4. PMID 23921380, Free PMC Article
    3. A B-cell-specific DNA recombination complex. Borggrefe T, et al. J Biol Chem, 1998 Jul 3. PMID 9642267
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell-cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-serine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic cell DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    switch-associated protein 70
    Names
    SWA-70 protein
    SWAP complex protein
    SWAP switching B-cell complex 70
    SWAP-70 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106288.1 → NP_001099758.1  switch-associated protein 70

      See identical proteins and their annotated locations for NP_001099758.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473956
      UniProtKB/TrEMBL
      A6I811, D3ZRE7
      Related
      ENSRNOP00000013276.6, ENSRNOT00000013276.7
      Conserved Domains (2) summary
      cd13273
      Location:204 → 313
      PH_SWAP-70; Switch-associated protein-70 Pleckstrin homology (PH) domain
      TIGR02168
      Location:332 → 549
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      173702338..173763540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588986.3 → XP_017444475.3  switch-associated protein 70 isoform X1

    2. XM_063285799.1 → XP_063141869.1  switch-associated protein 70 isoform X2

      UniProtKB/TrEMBL
      A6I813
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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