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    Psen1 presenilin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29192, updated on 18-Nov-2018

    Summary

    Official Symbol
    Psen1provided by RGD
    Official Full Name
    presenilin 1provided by RGD
    Primary source
    RGD:3425
    See related
    Ensembl:ENSRNOG00000009110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    multitransmembrane protein; human homolog mutated in most cases of early onset familial Alzheimer's disease; may mediate retinal lamination and pattern formation [RGD, Feb 2006]
    Expression
    Biased expression in Kidney (RPKM 210.6), Adrenal (RPKM 141.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Psen1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107169514..107221000)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 6 NC_005105.3 (118324910..118373090, complement)

    Chromosome 6 - NC_005105.4Genomic Context describing neighboring genes Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene uncharacterized LOC102547293 Neighboring gene RNA binding motif protein 25 Neighboring gene papilin, proteoglycan-like sulfated glycoprotein Neighboring gene NUMB, endocytic adaptor protein Neighboring gene HEAT repeat containing 4 Neighboring gene ribosomal oxygenase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling, organism-specific biosystem (from KEGG)
      Notch signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Notch signaling, conserved biosystem (from KEGG)
      Notch signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
    • Notch signaling pathway, organism-specific biosystem (from KEGG)
      Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Notch signaling pathway, conserved biosystem (from KEGG)
      Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    aspartic endopeptidase activity, intramembrane cleaving ISO
    Inferred from Sequence Orthology
    more info
     
    aspartic endopeptidase activity, intramembrane cleaving ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Cajal-Retzius cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Cajal-Retzius cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Notch receptor processing IEA
    Inferred from Electronic Annotation
    more info
     
    Notch receptor processing ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    T cell activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid precursor protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid precursor protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
     
    amyloid-beta formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    brain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    brain morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate specification IEA
    Inferred from Electronic Annotation
    more info
     
    cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amyloid-beta IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    cerebellum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cerebral cortex cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    choline transport IEA
    Inferred from Electronic Annotation
    more info
     
    choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal/ventral neural tube patterning IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic limb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    eye photoreceptor cell development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    forebrain development ISO
    Inferred from Sequence Orthology
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    locomotion ISO
    Inferred from Sequence Orthology
    more info
     
    membrane protein ectodomain proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    membrane protein ectodomain proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    memory IEA
    Inferred from Electronic Annotation
    more info
     
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial transport ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of age-related behavioral decline IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of age-related behavioral decline ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    myeloid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of core promoter binding IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT negative regulation of low-density lipoprotein receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neural retina development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-glutamate import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor recycling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein maturation ISO
    Inferred from Sequence Orthology
    more info
     
    protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    protein processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of resting membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of resting membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    segmentation ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    skin morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    skin morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    smooth endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle targeting IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle targeting ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    aggresome ISO
    Inferred from Sequence Orthology
    more info
     
    aggresome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary rootlet ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    gamma-secretase complex ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-secretase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    presenilin-1
    Names
    PS-1
    NP_062036.2
    XP_006240383.1
    XP_006240384.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019163.3NP_062036.2  presenilin-1

      See identical proteins and their annotated locations for NP_062036.2

      Status: PROVISIONAL

      Source sequence(s)
      D82578
      UniProtKB/Swiss-Prot
      P97887
      Conserved Domains (1) summary
      pfam01080
      Location:76458
      Presenilin; Presenilin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005105.4 Reference Rnor_6.0 Primary Assembly

      Range
      107169514..107221000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240321.3XP_006240383.1  presenilin-1 isoform X1

      See identical proteins and their annotated locations for XP_006240383.1

      UniProtKB/Swiss-Prot
      P97887
      Related
      ENSRNOP00000012495.4, ENSRNOT00000012495.7
      Conserved Domains (1) summary
      pfam01080
      Location:76458
      Presenilin; Presenilin
    2. XM_006240322.3XP_006240384.1  presenilin-1 isoform X1

      See identical proteins and their annotated locations for XP_006240384.1

      UniProtKB/Swiss-Prot
      P97887
      Conserved Domains (1) summary
      pfam01080
      Location:76458
      Presenilin; Presenilin

    Alternate Rn_Celera

    Genomic

    1. AC_000074.1 Alternate Rn_Celera

      Range
      101163513..101199486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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