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    Cdh10 cadherin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29181, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cdh10provided by RGD
    Official Full Name
    cadherin 10provided by RGD
    Primary source
    RGD:619741
    See related
    Ensembl:ENSRNOG00000009771 AllianceGenome:RGD:619741
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic active zone membrane. Orthologous to human CDH10 (cadherin 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 120.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (70355521..70577880)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (68628623..68850995)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (69415174..69636849)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene protein crumbs homolog 3-like Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC120100745 Neighboring gene uncharacterized LOC120100746 Neighboring gene RB binding protein 9, serine hydrolase, pseudogene 1 Neighboring gene uncharacterized LOC102553625 Neighboring gene uncharacterized LOC102553734 Neighboring gene uncharacterized LOC120100560

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins. Smith KR, et al. J Neurosci, 2017 Nov 15. PMID 29030434, Free PMC Article
    2. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, et al. Endocrinology, 2000 Feb. PMID 10650949
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cadherin-10 forms nanoscale puncta at excitatory and inhibitory synapses in neuronal dendrites.
      Title: Cadherin-10 Maintains Excitatory/Inhibitory Ratio through Interactions with Synaptic Proteins.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168631.1 → NP_001162102.1  cadherin-10 precursor

      See identical proteins and their annotated locations for NP_001162102.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6JMU7, F1LR98
      Related
      ENSRNOP00000013152.1, ENSRNOT00000013152.5
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:643 → 780
      Cadherin_C; Cadherin cytoplasmic region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      70355521..70577880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232080.5 → XP_006232142.1  cadherin-10 isoform X2

      UniProtKB/TrEMBL
      A6JMU7
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:641 → 778
      Cadherin_C; Cadherin cytoplasmic region

    2. XM_006232079.5 → XP_006232141.1  cadherin-10 isoform X1

      See identical proteins and their annotated locations for XP_006232141.1

      UniProtKB/TrEMBL
      A6JMU7, F1LR98
      Conserved Domains (3) summary
      cd11304
      Location:164 → 265
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00112
      Location:80 → 158
      CA; Cadherin repeats
      pfam01049
      Location:643 → 780
      Cadherin_C; Cadherin cytoplasmic region
    Nucleotide Protein Strain
    Heading Accession and Version

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