LGALS13 galectin 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALS13provided by HGNC
Official Full Name: galectin 13provided by HGNC
Primary source: HGNC:HGNC:15449
See related: Ensembl:ENSG00000105198 MIM:608717; AllianceGenome:HGNC:15449
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PP13; GAL13; PLAC8
Summary: Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward placenta (RPKM 6.7) See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39602524..39607474)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42406672..42411734)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (40093164..40098114)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
Title: [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus].
Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
Title: Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth.
Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
Title: Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids.
Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
Title: Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease.
PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
Title: PLACENTAL BIOMARKERS: PP13, VEGF IN DIAGNOSTICS OF EARLY AND LATE PREECLAMPSIA.
[Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
Title: [Expression of galectin-13 in allergic diseases involving airway, skin and mucous membranes].
Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
Title: Increased epithelial galectin-13 expression associates with eosinophilic airway inflammation in asthma.
Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
Title: Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype.
Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
Title: Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution.
These results indicate that Gal-13 is not a normal galectin, which could not bind to beta-galactosides. Lastly, the distribution of EGFP-tagged wild-type Gal-13 and its variants in HeLa cells showed that they are concentrated in the nucleus and could be co-localized within filamentary materials, possibly actin.
Title: Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-R31571 (e-PCR)
- UniSTS:26666

NoName (e-PCR)
- UniSTS:481131

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: galactoside-binding soluble lectin 13

Names: beta-galactoside-binding lectin; gal-13; lectin, galactoside-binding, soluble, 13; placental protein 13; placental tissue protein 13

NP_037400.1

EC 3.1.1.5

XP_011525176.2

EC 3.1.1.5

XP_024307242.1

EC 3.1.1.5

XP_054176728.1

EC 3.1.1.5

XP_054176729.1

EC 3.1.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013268.3 → NP_037400.1 galactoside-binding soluble lectin 13

See identical proteins and their annotated locations for NP_037400.1

Status: REVIEWED

Source sequence(s)

AC005205

Consensus CDS

CCDS33024.1

UniProtKB/Swiss-Prot

C5HZ15, Q9UHV8

Related

ENSP00000221797.3, ENST00000221797.5

Conserved Domains (1) summary

smart00908
Location:11 → 135

Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

39602524..39607474

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024451474.2 → XP_024307242.1 galactoside-binding soluble lectin 13 isoform X2

Conserved Domains (1) summary

smart00908
Location:42 → 166

Gal-bind_lectin; Galactoside-binding lectin
XM_011526874.3 → XP_011525176.2 galactoside-binding soluble lectin 13 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

42406672..42411734

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320754.1 → XP_054176729.1 galactoside-binding soluble lectin 13 isoform X2
XM_054320753.1 → XP_054176728.1 galactoside-binding soluble lectin 13 isoform X1