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    TAGLN3 transgelin 3 [ Homo sapiens (human) ]

    Gene ID: 29114, updated on 15-Jun-2019

    Summary

    Official Symbol
    TAGLN3provided by HGNC
    Official Full Name
    transgelin 3provided by HGNC
    Primary source
    HGNC:HGNC:29868
    See related
    Ensembl:ENSG00000144834 MIM:607953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP22; NP24; NP25
    Expression
    Restricted expression toward brain (RPKM 97.4) See more
    Orthologs

    Genomic context

    See TAGLN3 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (111998739..112013888)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (111717586..111732735)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol specific phospholipase C X domain containing 2 Neighboring gene pleckstrin homology like domain family B member 2 Neighboring gene uncharacterized LOC105374040 Neighboring gene abhydrolase domain containing 10 Neighboring gene transmembrane serine protease 7 Neighboring gene riboflavin kinase pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transgelin-3
    Names
    neuronal protein 22
    neuronal protein NP25

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008272.2NP_001008273.1  transgelin-3

      See identical proteins and their annotated locations for NP_001008273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC015329, BI752099, BM894229
      Consensus CDS
      CCDS33816.1
      UniProtKB/Swiss-Prot
      Q9UI15
      Related
      ENSP00000419105.1, ENST00000478951.6
      Conserved Domains (2) summary
      cd00014
      Location:25133
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:174197
      Calponin; Calponin family repeat
    2. NM_001008273.1NP_001008274.1  transgelin-3

      See identical proteins and their annotated locations for NP_001008274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BG912462, BI822856, BM894229, CK003985
      Consensus CDS
      CCDS33816.1
      UniProtKB/Swiss-Prot
      Q9UI15
      Related
      ENSP00000391160.2, ENST00000455401.6
      Conserved Domains (2) summary
      cd00014
      Location:25133
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:174197
      Calponin; Calponin family repeat
    3. NM_013259.2NP_037391.2  transgelin-3

      See identical proteins and their annotated locations for NP_037391.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AF112201, BI919263, BM894229, BQ640029
      Consensus CDS
      CCDS33816.1
      UniProtKB/Swiss-Prot
      Q9UI15
      Related
      ENSP00000377494.2, ENST00000393917.6
      Conserved Domains (2) summary
      cd00014
      Location:25133
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam00402
      Location:174197
      Calponin; Calponin family repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      111998739..112013888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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