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    MRPL22 mitochondrial ribosomal protein L22 [ Homo sapiens (human) ]

    Gene ID: 29093, updated on 12-May-2019

    Summary

    Official Symbol
    MRPL22provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L22provided by HGNC
    Primary source
    HGNC:HGNC:14480
    See related
    Ensembl:ENSG00000082515 MIM:611835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L22mt; RPML25; HSPC158; MRP-L22; MRP-L25
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 4.5), adrenal (RPKM 4.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See MRPL22 in Genome Data Viewer
    Location:
    5q33.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (154941073..154969411)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154320633..154348971)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CCR4-NOT transcription complex subunit 8 Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene kinesin family member 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from BioSystems

    • Mitochondrial translation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
    • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
    • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
    • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
      Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Ribosome, organism-specific biosystem (from KEGG)
      Ribosome, organism-specific biosystem
      Ribosome
    • Ribosome, conserved biosystem (from KEGG)
      Ribosome, conserved biosystem
      Ribosome

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp781F1071

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
     
    ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    39S ribosomal protein L22, mitochondrial
    Names
    39S ribosomal protein L25, mitochondrial
    L25mt
    mitochondrial large ribosomal subunit protein uL22m

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014990.2NP_001014990.1  39S ribosomal protein L22, mitochondrial isoform b

      See identical proteins and their annotated locations for NP_001014990.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC008410, BP372420, CR933679
      Consensus CDS
      CCDS43391.1
      UniProtKB/Swiss-Prot
      Q9NWU5
      Related
      ENSP00000265229.8, ENST00000265229.12
      Conserved Domains (1) summary
      pfam00237
      Location:192
      Ribosomal_L22; Ribosomal protein L22p/L17e
    2. NM_014180.4NP_054899.2  39S ribosomal protein L22, mitochondrial isoform a

      See identical proteins and their annotated locations for NP_054899.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC008410, AK000601, BP372420, CR933679
      Consensus CDS
      CCDS4331.1
      UniProtKB/Swiss-Prot
      Q9NWU5
      Related
      ENSP00000431040.1, ENST00000523037.6
      Conserved Domains (1) summary
      pfam00237
      Location:71172
      Ribosomal_L22; Ribosomal protein L22p/L17e

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      154941073..154969411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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