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    GRIK5 glutamate ionotropic receptor kainate type subunit 5 [ Homo sapiens (human) ]

    Gene ID: 2901, updated on 17-Jun-2019

    Summary

    Official Symbol
    GRIK5provided by HGNC
    Official Full Name
    glutamate ionotropic receptor kainate type subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:4583
    See related
    Ensembl:ENSG00000105737 MIM:600283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KA2; EAA2; GRIK2; GluK5
    Summary
    This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in testis (RPKM 5.6), brain (RPKM 5.5) and 14 other tissues See more
    Orthologs

    Genomic context

    See GRIK5 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41998316..42071804, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42502468..42574278, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Rab acceptor 1 Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene Sharpr-MPRA regulatory regions 411/7488 and 4104 Neighboring gene zinc finger protein 574 Neighboring gene POU class 2 homeobox 2 Neighboring gene uncharacterized LOC100505622 Neighboring gene microRNA 4323 Neighboring gene death effector domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    kainate selective glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kainate selective glutamate receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein retention in ER lumen IEA
    Inferred from Electronic Annotation
    more info
     
    receptor clustering IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic vesicle fusion to presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    kainate selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutamate receptor ionotropic, kainate 5
    Names
    excitatory amino acid receptor 2
    glutamate receptor KA2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301030.1NP_001287959.1  glutamate receptor ionotropic, kainate 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001287959.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC010616, AJ249209, BM152516
      Consensus CDS
      CCDS77305.1
      UniProtKB/Swiss-Prot
      Q16478
      Related
      ENSP00000301218.3, ENST00000301218.8
      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. NM_002088.4NP_002079.3  glutamate receptor ionotropic, kainate 5 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002079.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      BC037358, BC131717, CA432656
      Consensus CDS
      CCDS12595.1
      UniProtKB/Swiss-Prot
      Q16478
      Related
      ENSP00000262895.2, ENST00000262895.7
      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      41998316..42071804 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258821.3XP_005258878.1  glutamate receptor ionotropic, kainate 5 isoform X3

      See identical proteins and their annotated locations for XP_005258878.1

      UniProtKB/Swiss-Prot
      Q16478
      Related
      ENSP00000470251.1, ENST00000593562.5
      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    2. XM_011526862.2XP_011525164.1  glutamate receptor ionotropic, kainate 5 isoform X1

      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:546816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414785
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    3. XM_011526868.1XP_011525170.1  glutamate receptor ionotropic, kainate 5 isoform X7

      Conserved Domains (4) summary
      pfam00060
      Location:465735
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1298
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1318
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:333704
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    4. XM_011526865.1XP_011525167.1  glutamate receptor ionotropic, kainate 5 isoform X4

      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:546816
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414785
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    5. XM_011526867.1XP_011525169.1  glutamate receptor ionotropic, kainate 5 isoform X6

      Conserved Domains (4) summary
      pfam00060
      Location:477747
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:13311
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:14331
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:346716
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    6. XM_017026713.1XP_016882202.1  glutamate receptor ionotropic, kainate 5 isoform X5

      Conserved Domains (4) summary
      pfam00060
      Location:478748
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:13311
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:14331
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
      cl21456
      Location:346717
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    7. XM_011526863.2XP_011525165.1  glutamate receptor ionotropic, kainate 5 isoform X2

      See identical proteins and their annotated locations for XP_011525165.1

      UniProtKB/Swiss-Prot
      Q16478
      Conserved Domains (4) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam00060
      Location:545815
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414784
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    8. XM_011526869.2XP_011525171.1  glutamate receptor ionotropic, kainate 5 isoform X8

      Conserved Domains (3) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414613
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    9. XM_011526871.2XP_011525173.1  glutamate receptor ionotropic, kainate 5 isoform X10

      Conserved Domains (3) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414491
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    10. XM_011526870.2XP_011525172.1  glutamate receptor ionotropic, kainate 5 isoform X9

      Conserved Domains (3) summary
      cd06394
      Location:25399
      PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor
      pfam01094
      Location:42379
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:414491
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    RNA

    1. XR_935810.2 RNA Sequence

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