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    KLF15 KLF transcription factor 15 [ Homo sapiens (human) ]

    Gene ID: 28999, updated on 10-Dec-2024

    Summary

    Official Symbol
    KLF15provided by HGNC
    Official Full Name
    KLF transcription factor 15provided by HGNC
    Primary source
    HGNC:HGNC:14536
    See related
    Ensembl:ENSG00000163884 MIM:606465; AllianceGenome:HGNC:14536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KKLF
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KLF15 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (126288125..126357408, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (129020460..129089956, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (126061478..126076251, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family member L1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125899089-125899844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125899845-125900598 Neighboring gene ALDH1L1 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 2719 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20437 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:125926972-125928171 Neighboring gene uncharacterized LOC124909426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125932350-125932862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125977069-125977976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125985551-125986260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:125986261-125986971 Neighboring gene uncharacterized LOC107986124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126006839-126007384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:126007385-126007929 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:126010617-126011117 Neighboring gene MPRA-validated peak4813 silencer Neighboring gene uncharacterized LOC105374088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126050110-126050714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126050715-126051318 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:126060213-126060974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126062507-126063190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126074793-126075552 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:126075553-126076312 Neighboring gene NANOG hESC enhancer GRCh37_chr3:126081217-126081718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:126094973-126095585 Neighboring gene uncharacterized LOC107986044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:126108375-126108923 Neighboring gene CFAP100 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp779M1320

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cardiac muscle hypertrophy in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of D-glucose import IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Krueppel-like factor 15
    Names
    Kruppel like factor 15
    kidney-enriched Kruppel-like factor
    kidney-enriched krueppel-like factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014079.4NP_054798.1  Krueppel-like factor 15

      See identical proteins and their annotated locations for NP_054798.1

      Status: VALIDATED

      Source sequence(s)
      AC063919, BC036733
      Consensus CDS
      CCDS3036.1
      UniProtKB/Swiss-Prot
      Q9UIH9
      Related
      ENSP00000296233.3, ENST00000296233.4
      Conserved Domains (2) summary
      COG5189
      Location:306401
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:323345
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      126288125..126357408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512743.3XP_011511045.1  Krueppel-like factor 15 isoform X1

      Conserved Domains (4) summary
      sd00017
      Location:342364
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:340364
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:386411
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:342421
      zf-C2H2_8; C2H2-type zinc ribbon

    RNA

    1. XR_001740124.3 RNA Sequence

    2. XR_924449.3 RNA Sequence

    3. XR_002959509.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      129020460..129089956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346365.1XP_054202340.1  Krueppel-like factor 15 isoform X1

    RNA

    1. XR_008486709.1 RNA Sequence

    2. XR_008486707.1 RNA Sequence

    3. XR_008486708.1 RNA Sequence