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    HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 28996, updated on 17-Mar-2024

    Summary

    Official Symbol
    HIPK2provided by HGNC
    Official Full Name
    homeodomain interacting protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:14402
    See related
    Ensembl:ENSG00000064393 MIM:606868; AllianceGenome:HGNC:14402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO0593
    Summary
    This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in brain (RPKM 22.7), kidney (RPKM 17.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    7q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (139561570..139777998, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (140874868..141091290, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139246316..139477797, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein pseudogene 17 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139226381-139227154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139229072-139229673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26764 Neighboring gene C-type lectin domain family 2 member L Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253336-139253836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139253837-139254337 Neighboring gene ERH pseudogene 1 Neighboring gene uncharacterized LOC105375530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26765 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:139311135-139311345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:139365244-139366443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26767 Neighboring gene NANOG hESC enhancer GRCh37_chr7:139377579-139378080 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:139411674-139412500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139415914-139416414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139416415-139416915 Neighboring gene Sharpr-MPRA regulatory region 6205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18700 Neighboring gene Sharpr-MPRA regulatory region 3006 Neighboring gene MPRA-validated peak6784 silencer Neighboring gene thromboxane A synthase 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:139528736-139529935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26770 Neighboring gene uncharacterized LOC107986853 Neighboring gene Sharpr-MPRA regulatory region 12519 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:139613504-139614703 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:139615605-139616804 Neighboring gene uncharacterized LOC105375532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:139637955-139638455

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23711, DKFZp686K02111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables virion binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in PML body organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic retina morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression TAS
    Traceable Author Statement
    more info
     
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in iris morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lens induction in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina layer formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeodomain-interacting protein kinase 2
    Names
    hHIPk2
    NP_001106710.1
    NP_073577.3
    XP_011514379.1
    XP_011514380.1
    XP_011514381.1
    XP_011514382.1
    XP_011514383.1
    XP_047276216.1
    XP_047276217.1
    XP_047276218.1
    XP_047276219.1
    XP_047276220.1
    XP_047276221.1
    XP_054213962.1
    XP_054213963.1
    XP_054213964.1
    XP_054213965.1
    XP_054213966.1
    XP_054213967.1
    XP_054213968.1
    XP_054213969.1
    XP_054213970.1
    XP_054213971.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113239.3NP_001106710.1  homeodomain-interacting protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_001106710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter, as compared to isoform 1.
      Source sequence(s)
      AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
      Consensus CDS
      CCDS75666.1
      UniProtKB/Swiss-Prot
      Q9H2X6
      Related
      ENSP00000413724.2, ENST00000428878.6
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. NM_022740.5NP_073577.3  homeodomain-interacting protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_073577.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the full-length isoform (1).
      Source sequence(s)
      AC005531, AC006021, AF208291, AF326592, AI580907, CK818532
      Consensus CDS
      CCDS75667.1
      UniProtKB/Swiss-Prot
      Q75MR7, Q8WWI4, Q9H2X6, Q9H2Y1
      Related
      ENSP00000385571.3, ENST00000406875.8
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      139561570..139777998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420265.1XP_047276221.1  homeodomain-interacting protein kinase 2 isoform X8

    2. XM_047420260.1XP_047276216.1  homeodomain-interacting protein kinase 2 isoform X6

    3. XM_047420264.1XP_047276220.1  homeodomain-interacting protein kinase 2 isoform X7

    4. XM_047420261.1XP_047276217.1  homeodomain-interacting protein kinase 2 isoform X7

    5. XM_047420262.1XP_047276218.1  homeodomain-interacting protein kinase 2 isoform X7

    6. XM_047420263.1XP_047276219.1  homeodomain-interacting protein kinase 2 isoform X7

    7. XM_011516080.4XP_011514382.1  homeodomain-interacting protein kinase 2 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    8. XM_011516079.4XP_011514381.1  homeodomain-interacting protein kinase 2 isoform X3

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    9. XM_011516078.4XP_011514380.1  homeodomain-interacting protein kinase 2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    10. XM_011516077.4XP_011514379.1  homeodomain-interacting protein kinase 2 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    11. XM_011516081.3XP_011514383.1  homeodomain-interacting protein kinase 2 isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:207535
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:191545
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      140874868..141091290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357996.1XP_054213971.1  homeodomain-interacting protein kinase 2 isoform X8

    2. XM_054357992.1XP_054213967.1  homeodomain-interacting protein kinase 2 isoform X6

    3. XM_054357995.1XP_054213970.1  homeodomain-interacting protein kinase 2 isoform X7

    4. XM_054357993.1XP_054213968.1  homeodomain-interacting protein kinase 2 isoform X7

    5. XM_054357994.1XP_054213969.1  homeodomain-interacting protein kinase 2 isoform X7

    6. XM_054357990.1XP_054213965.1  homeodomain-interacting protein kinase 2 isoform X4

    7. XM_054357989.1XP_054213964.1  homeodomain-interacting protein kinase 2 isoform X3

    8. XM_054357988.1XP_054213963.1  homeodomain-interacting protein kinase 2 isoform X2

    9. XM_054357987.1XP_054213962.1  homeodomain-interacting protein kinase 2 isoform X1

    10. XM_054357991.1XP_054213966.1  homeodomain-interacting protein kinase 2 isoform X5