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    ASTE1 asteroid homolog 1 [ Homo sapiens (human) ]

    Gene ID: 28990, updated on 15-Jun-2019

    Summary

    Official Symbol
    ASTE1provided by HGNC
    Official Full Name
    asteroid homolog 1provided by HGNC
    Primary source
    HGNC:HGNC:25021
    See related
    Ensembl:ENSG00000034533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HT001
    Expression
    Ubiquitous expression in testis (RPKM 3.6), thyroid (RPKM 3.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ASTE1 in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (131013873..131026854, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130732721..130745698, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene cysteine and glycine rich protein 2 pseudogene Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene uncharacterized LOC107986024 Neighboring gene NIMA related kinase 11 Neighboring gene RNA, U6 small nuclear 726, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC129980

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid phosphodiester bond hydrolysis IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288950.1NP_001275879.1  protein asteroid homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_001275879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK294156, BC069265, BM992874
      Consensus CDS
      CCDS75007.1
      UniProtKB/Swiss-Prot
      Q2TB18
      UniProtKB/TrEMBL
      D6RG30
      Related
      ENSP00000426421.1, ENST00000514044.5
      Conserved Domains (1) summary
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. NM_014065.3NP_054784.2  protein asteroid homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_054784.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK027806, AK294156, BC069265, BM992874
      Consensus CDS
      CCDS3068.1
      UniProtKB/Swiss-Prot
      Q2TB18
      Related
      ENSP00000264992.3, ENST00000264992.7
      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily

    RNA

    1. NR_110229.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and lacks an alternate internal exon and contains an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK294156, BC069265, BM992874

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      131013873..131026854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453486.1XP_024309254.1  protein asteroid homolog 1 isoform X1

      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    2. XM_017006268.2XP_016861757.1  protein asteroid homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2TB18
      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    3. XM_017006267.2XP_016861756.1  protein asteroid homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2TB18
      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    4. XM_017006266.2XP_016861755.1  protein asteroid homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2TB18
      Related
      ENSP00000421019.1, ENST00000507978.5
      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
    5. XM_017006269.2XP_016861758.1  protein asteroid homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q2TB18
      Conserved Domains (2) summary
      pfam12813
      Location:116168
      XPG_I_2; XPG domain containing
      cl14812
      Location:197
      PIN_SF; PIN (PilT N terminus) domain: Superfamily
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