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    GRB10 growth factor receptor bound protein 10 [ Homo sapiens (human) ]

    Gene ID: 2887, updated on 22-Aug-2021

    Summary

    Official Symbol
    GRB10provided by HGNC
    Official Full Name
    growth factor receptor bound protein 10provided by HGNC
    Primary source
    HGNC:HGNC:4564
    See related
    Ensembl:ENSG00000106070 MIM:601523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RSS; IRBP; MEG1; GRB-IR; Grb-10
    Summary
    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.6), kidney (RPKM 5.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRB10 in Genome Data Viewer
    Location:
    7p12.1
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (50590068..50793453, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (50657765..50861150, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9793 Neighboring gene dopa decarboxylase Neighboring gene DDC antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 14531 Neighboring gene ribosomal protein L39 pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.
    GeneReviews: Not available
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    GeneReviews: Not available
    Gene-Smoking Interactions Identify Several Novel Blood Pressure Loci in the Framingham Heart Study.
    GeneReviews: Not available
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    GeneReviews: Not available
    Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
    GeneReviews: Not available
    Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.
    GeneReviews: Not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-03-23)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-03-23)

    ClinGen Genome Curation Page

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0207

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables insulin receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor complex adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    growth factor receptor-bound protein 10
    Names
    GRB10 adapter protein
    GRB10 adaptor protein
    insulin receptor-binding protein Grb-IR
    maternally expressed gene 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012305.2 RefSeqGene

      Range
      5010..208395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1032

    mRNA and Protein(s)

    1. NM_001001549.3NP_001001549.1  growth factor receptor-bound protein 10 isoform b

      See identical proteins and their annotated locations for NP_001001549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as hGrb10alpha, lacks an in-frame segment in the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
      Source sequence(s)
      AC005153, AC080092
      Consensus CDS
      CCDS47586.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000349818.5, ENST00000357271.9
      Conserved Domains (4) summary
      cd01787
      Location:166248
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:441548
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:283362
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:380421
      BPS; BPS (Between PH and SH2)
    2. NM_001001550.3NP_001001550.1  growth factor receptor-bound protein 10 isoform c

      See identical proteins and their annotated locations for NP_001001550.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as hGrb10beta, differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 4, 6, and 7.
      Source sequence(s)
      AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000381790.2, ENST00000398810.6
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    3. NM_001001555.3NP_001001555.1  growth factor receptor-bound protein 10 isoform c

      See identical proteins and their annotated locations for NP_001001555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a. Isoform c is encoded by transcript variants 3, 4, 6, and 7.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43583.1
      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000338543.3, ENST00000335866.7
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    4. NM_001350814.2NP_001337743.1  growth factor receptor-bound protein 10 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS43582.1
      Related
      ENSP00000385770.1, ENST00000401949.6
      Conserved Domains (4) summary
      cd01787
      Location:166248
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:487594
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:286408
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:426467
      BPS; BPS (Between PH and SH2)
    5. NM_001350815.2NP_001337744.1  growth factor receptor-bound protein 10 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform d.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS87504.1
      Related
      ENSP00000493728.1, ENST00000644879.1
      Conserved Domains (4) summary
      cd01787
      Location:204286
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:525632
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:324446
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:464505
      BPS; BPS (Between PH and SH2)
    6. NM_001350816.3NP_001337745.2  growth factor receptor-bound protein 10 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 3, 4, and 7, encodes isoform c.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Consensus CDS
      CCDS87503.1
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    7. NM_001371008.1NP_001357937.1  growth factor receptor-bound protein 10 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AC004920, AC005153, AC080092
      Related
      ENSP00000495341.2, ENST00000645075.2
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    8. NM_001371009.1NP_001357938.1  growth factor receptor-bound protein 10 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) encodes the longest isoform (f).
      Source sequence(s)
      AC004920, AC005153, AC080092
      Conserved Domains (4) summary
      cd10415
      Location:536643
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:335457
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:215306
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:475516
      BPS; BPS (Between PH and SH2)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      50590068..50793453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012043.1XP_016867532.1  growth factor receptor-bound protein 10 isoform X6

    2. XM_017012042.2XP_016867531.1  growth factor receptor-bound protein 10 isoform X6

    3. XM_017012061.2XP_016867550.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    4. XM_017012059.2XP_016867548.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    5. XM_024446729.1XP_024302497.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    6. XM_017012034.1XP_016867523.1  growth factor receptor-bound protein 10 isoform X5

    7. XM_024446726.1XP_024302494.1  growth factor receptor-bound protein 10 isoform X3

      Conserved Domains (4) summary
      cd01787
      Location:250331
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:570677
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:369491
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:509550
      BPS; BPS (Between PH and SH2)
    8. XM_024446730.1XP_024302498.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    9. XM_017012030.2XP_016867519.1  growth factor receptor-bound protein 10 isoform X2

    10. XM_017012031.2XP_016867520.1  growth factor receptor-bound protein 10 isoform X4

    11. XM_017012029.2XP_016867518.1  growth factor receptor-bound protein 10 isoform X1

    12. XM_017012033.1XP_016867522.1  growth factor receptor-bound protein 10 isoform X5

    13. XM_017012040.2XP_016867529.1  growth factor receptor-bound protein 10 isoform X6

    14. XM_017012038.2XP_016867527.1  growth factor receptor-bound protein 10 isoform X6

    15. XM_017012037.2XP_016867526.1  growth factor receptor-bound protein 10 isoform X6

    16. XM_017012036.2XP_016867525.1  growth factor receptor-bound protein 10 isoform X6

    17. XM_017012060.2XP_016867549.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    18. XM_017012055.2XP_016867544.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    19. XM_017012054.2XP_016867543.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    20. XM_017012050.2XP_016867539.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    21. XM_017012053.2XP_016867542.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    22. XM_017012049.2XP_016867538.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    23. XM_017012048.2XP_016867537.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    24. XM_017012047.2XP_016867536.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    25. XM_024446728.1XP_024302496.1  growth factor receptor-bound protein 10 isoform X9

      Conserved Domains (4) summary
      cd01787
      Location:160242
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:481588
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:280402
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:420461
      BPS; BPS (Between PH and SH2)
    26. XM_017012046.2XP_016867535.1  growth factor receptor-bound protein 10 isoform X8

      UniProtKB/Swiss-Prot
      Q13322
      Conserved Domains (4) summary
      cd01787
      Location:166248
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:487594
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:286408
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:426467
      BPS; BPS (Between PH and SH2)
    27. XM_017012032.1XP_016867521.1  growth factor receptor-bound protein 10 isoform X5

    28. XM_017012064.2XP_016867553.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    29. XM_017012063.2XP_016867552.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    30. XM_017012068.2XP_016867557.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    31. XM_017012065.2XP_016867554.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    32. XM_017012056.2XP_016867545.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    33. XM_011515316.1XP_011513618.1  growth factor receptor-bound protein 10 isoform X7

      See identical proteins and their annotated locations for XP_011513618.1

      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000385366.1, ENST00000406641.5
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    34. XM_017012067.1XP_016867556.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000496245.1, ENST00000643299.1
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    35. XM_017012039.1XP_016867528.1  growth factor receptor-bound protein 10 isoform X6

    36. XM_017012058.1XP_016867547.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    37. XM_017012062.2XP_016867551.1  growth factor receptor-bound protein 10 isoform X10

      Conserved Domains (4) summary
      cd01787
      Location:154235
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:474581
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:273395
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam08947
      Location:413454
      BPS; BPS (Between PH and SH2)
    38. XM_017012045.1XP_016867534.1  growth factor receptor-bound protein 10 isoform X7

      UniProtKB/Swiss-Prot
      Q13322
      Related
      ENSP00000385189.1, ENST00000402578.5
      Conserved Domains (4) summary
      cd10415
      Location:429536
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:228350
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      cd16141
      Location:108199
      RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
      pfam08947
      Location:368409
      BPS; BPS (Between PH and SH2)
    39. XM_011515323.3XP_011513625.1  growth factor receptor-bound protein 10 isoform X11

      Conserved Domains (5) summary
      cd01787
      Location:106187
      GRB7_RA; RA (RAS-associated like) domain of Grb7
      cd10415
      Location:426533
      SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins
      cd01259
      Location:225347
      PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain
      pfam00169
      Location:230338
      PH; PH domain
      pfam08947
      Location:365406
      BPS; BPS (Between PH and SH2)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_005311.4: Suppressed sequence

      Description
      NM_005311.4: This RefSeq was removed because currently there is insufficient support for the transcript.
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