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    GRB2 growth factor receptor bound protein 2 [ Homo sapiens (human) ]

    Gene ID: 2885, updated on 27-May-2024

    Summary

    Official Symbol
    GRB2provided by HGNC
    Official Full Name
    growth factor receptor bound protein 2provided by HGNC
    Primary source
    HGNC:HGNC:4566
    See related
    Ensembl:ENSG00000177885 MIM:108355; AllianceGenome:HGNC:4566
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
    Summary
    The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 63.6), appendix (RPKM 60.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRB2 in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75318076..75405678, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76210297..76297898, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73314157..73401759, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MIF4GD divergent transcript Neighboring gene solute carrier family 25 member 19 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:73284659-73285160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8963 Neighboring gene uncharacterized LOC124904059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73297250-73297750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12753 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:73315884-73317083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73322960-73323460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12757 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73341127-73342118 Neighboring gene ribosomal protein L36a pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73343103-73343271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73346323-73346862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73346863-73347400 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73348169-73348497 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:73376470-73377316 Neighboring gene MPRA-validated peak2996 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:73390107-73391015 Neighboring gene uncharacterized LOC124904060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8965 Neighboring gene RNA, U6 small nuclear 938, pseudogene Neighboring gene microRNA 3678

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Nef protein and potentiates HIV-1 LTR promoter activity PubMed
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Tat tat Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Tat protein and potentiates HIV-1 LTR promoter activity PubMed
    tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
    tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
    reverse transcriptase gag-pol HIV-1 RT is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ephrin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neurotrophin TRKA receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Schwann cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branching involved in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Grb2-EGFR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    growth factor receptor-bound protein 2
    Names
    HT027
    SH2/SH3 adapter GRB2
    abundant SRC homology
    epidermal growth factor receptor-binding protein GRB2
    epididymis secretory sperm binding protein
    growth factor receptor-bound protein 3
    protein Ash

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029556.1 RefSeqGene

      Range
      5032..92634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002086.5NP_002077.1  growth factor receptor-bound protein 2 isoform 1

      See identical proteins and their annotated locations for NP_002077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC011933
      Consensus CDS
      CCDS11721.1
      UniProtKB/Swiss-Prot
      P29354, P62993, Q14450, Q63057, Q63059
      UniProtKB/TrEMBL
      B0LPF3, B3KR50, Q6ICN0
      Related
      ENSP00000339007.4, ENST00000316804.10
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    2. NM_203506.3NP_987102.1  growth factor receptor-bound protein 2 isoform 2

      See identical proteins and their annotated locations for NP_987102.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. It encodes the shorter isoform (2) that lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC011933, BC000631, DA458680
      Consensus CDS
      CCDS11722.1
      UniProtKB/TrEMBL
      B3KR50, Q6ICN0
      Related
      ENSP00000317360.5, ENST00000316615.9
      Conserved Domains (2) summary
      cd09941
      Location:15109
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11949
      Location:119171
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75318076..75405678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76210297..76297898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)