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    TRARG1 trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene) [ Homo sapiens (human) ]

    Gene ID: 286753, updated on 25-Sep-2024

    Summary

    Official Symbol
    TRARG1provided by HGNC
    Official Full Name
    trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:29592
    See related
    Ensembl:ENSG00000184811 MIM:612211; AllianceGenome:HGNC:29592
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BEC-1; DSPB1; LOST1; TUSC5; IFITMD3
    Summary
    Predicted to be involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Predicted to act upstream of or within vesicle fusion to plasma membrane. Predicted to be located in cytoplasmic vesicle membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward fat (RPKM 61.1) See more
    Orthologs
    NEW
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    Genomic context

    See TRARG1 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (1279662..1300978)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (1171047..1192364)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (1182956..1204272)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ABR activator of RhoGEF and GTPase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11444 Neighboring gene MPRA-validated peak2673 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11446 Neighboring gene ABR antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1119641-1120638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1123483-1123982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1131887-1132591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11448 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:1167109-1167284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1170929-1171732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1171733-1172535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1174140-1174890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1202102-1202696 Neighboring gene basic helix-loop-helix family member a9 Neighboring gene Sharpr-MPRA regulatory region 14526 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1295206-1295734 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302101-1302738 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1303377-1304014 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1302739-1303376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1304957-1305572 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:1305573-1306188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335344-1335844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1335845-1336345 Neighboring gene Sharpr-MPRA regulatory region 4720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:1357059-1357560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:1358695-1359680 Neighboring gene CRK proto-oncogene, adaptor protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in endosome to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose import in response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle fusion to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    trafficking regulator of GLUT4 1
    Names
    brain endothelial cell derived gene-1
    dispanin subfamily B member 1
    interferon induced transmembrane protein domain containing 3
    interferon-induced transmembrane domain-containing protein D3
    located at seventeen p thirteen point three 1
    protein located at seventeen-p-thirteen point three 1
    tumor suppressor candidate 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172367.3NP_758955.2  trafficking regulator of GLUT4 1

      See identical proteins and their annotated locations for NP_758955.2

      Status: VALIDATED

      Source sequence(s)
      AC032044
      Consensus CDS
      CCDS42225.1
      UniProtKB/Swiss-Prot
      A6NMK4, Q8IXB3
      UniProtKB/TrEMBL
      A5PKU2
      Related
      ENSP00000329548.3, ENST00000333813.4
      Conserved Domains (1) summary
      pfam04505
      Location:92140
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      1279662..1300978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      1171047..1192364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)