Format

Send to:

Choose Destination
    • Showing Current items.

    FFAR2 free fatty acid receptor 2 [ Homo sapiens (human) ]

    Gene ID: 2867, updated on 15-Jun-2019

    Summary

    Official Symbol
    FFAR2provided by HGNC
    Official Full Name
    free fatty acid receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4501
    See related
    Ensembl:ENSG00000126262 MIM:603823
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FFA2R; GPR43
    Summary
    This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]
    Expression
    Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues See more
    Orthologs

    Genomic context

    See FFAR2 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (35447965..35451767)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35939185..35942669)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1531 Neighboring gene uncharacterized LOC101927522 Neighboring gene RNA, 7SL, cytoplasmic 491, pseudogene Neighboring gene keratinocyte differentiation associated protein Neighboring gene dermokine

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Free fatty acid receptors, organism-specific biosystem (from REACTOME)
      Free fatty acid receptors, organism-specific biosystemFatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120. Free fatty acid receptor 1 (FFAR1/GPR40) is activated b...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    cell surface pattern recognition receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to fatty acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte chemotaxis involved in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mucosal immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of acute inflammatory response to non-antigenic stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chemokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine production involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-8 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of acute inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of peptide hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    free fatty acid receptor 2
    Names
    G-protein coupled receptor 43
    fatty acid receptor 2
    free fatty acid activated receptor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370087.1NP_001357016.1  free fatty acid receptor 2

      Status: REVIEWED

      Source sequence(s)
      AC002511
    2. NM_005306.3NP_005297.1  free fatty acid receptor 2

      See identical proteins and their annotated locations for NP_005297.1

      Status: REVIEWED

      Source sequence(s)
      AC002511
      Consensus CDS
      CCDS12461.1
      UniProtKB/Swiss-Prot
      O15552
      UniProtKB/TrEMBL
      C6KYL4
      Related
      ENSP00000246549.2, ENST00000246549.2
      Conserved Domains (1) summary
      cd15170
      Location:9286
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      35448257..35451767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026711.1XP_016882200.1  free fatty acid receptor 2 isoform X1

      UniProtKB/Swiss-Prot
      O15552
      UniProtKB/TrEMBL
      C6KYL4
      Conserved Domains (1) summary
      cd15170
      Location:9286
      7tmA_FFAR2_FFAR3; free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Support Center