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    SCARA5 scavenger receptor class A member 5 [ Homo sapiens (human) ]

    Gene ID: 286133, updated on 17-Jun-2019

    Summary

    Official Symbol
    SCARA5provided by HGNC
    Official Full Name
    scavenger receptor class A member 5provided by HGNC
    Primary source
    HGNC:HGNC:28701
    See related
    Ensembl:ENSG00000168079 MIM:611306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Tesr; NET33
    Expression
    Broad expression in fat (RPKM 25.7), colon (RPKM 18.6) and 19 other tissues See more
    Orthologs

    Genomic context

    See SCARA5 in Genome Data Viewer
    Location:
    8p21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (27869883..27992673, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27727399..27850369, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa pseudogene Neighboring gene PDZ binding kinase Neighboring gene SCARA5 intron CAGE-defined high expression enhancer Neighboring gene VISTA enhancer hs1741 Neighboring gene uncharacterized LOC105379342 Neighboring gene microRNA 4287 Neighboring gene nuclear GTPase, germinal center associated Neighboring gene elongator acetyltransferase complex subunit 3 Neighboring gene uncharacterized LOC105379343

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
      Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
    • Scavenging by Class A Receptors, organism-specific biosystem (from REACTOME)
      Scavenging by Class A Receptors, organism-specific biosystemClass A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23907, MGC45780

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ferritin receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to heat IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    iron ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homotrimerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    scavenger receptor class A member 5
    Names
    scavenger receptor class A, member 5 (putative)
    scavenger receptor hlg
    testis expressed scavenger receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173833.6NP_776194.2  scavenger receptor class A member 5

      See identical proteins and their annotated locations for NP_776194.2

      Status: VALIDATED

      Source sequence(s)
      AC069113, AC104997
      Consensus CDS
      CCDS6064.1
      UniProtKB/Swiss-Prot
      Q6ZMJ2
      Related
      ENSP00000346990.3, ENST00000354914.8
      Conserved Domains (3) summary
      pfam01391
      Location:315373
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:393493
      SR; Scavenger receptor Cys-rich
      cl25732
      Location:90272
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      27869883..27992673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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