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    GPR37 G protein-coupled receptor 37 [ Homo sapiens (human) ]

    Gene ID: 2861, updated on 27-Nov-2024

    Summary

    Official Symbol
    GPR37provided by HGNC
    Official Full Name
    G protein-coupled receptor 37provided by HGNC
    Primary source
    HGNC:HGNC:4494
    See related
    Ensembl:ENSG00000170775 MIM:602583; AllianceGenome:HGNC:4494
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAELR; EDNRBL; hET(B)R-LP
    Summary
    This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
    Expression
    Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR37 in Genome Data Viewer
    Location:
    7q31.33
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (124743885..124765792, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (126061240..126083145, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (124383939..124405846, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2 pseudogene 31 Neighboring gene RNA, U6 small nuclear 102, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:124371425-124371925 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:124372079-124372580 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:124374223-124374759 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124397814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18589 Neighboring gene Sharpr-MPRA regulatory region 5263 Neighboring gene long intergenic non-protein coding RNA 3043 Neighboring gene Sharpr-MPRA regulatory region 10744 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124449868 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:124472442-124472991 Neighboring gene protection of telomeres 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:124533191-124533332 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:124542275 Neighboring gene Sharpr-MPRA regulatory region 5954

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study for reading and language abilities in two population cohorts.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neuropeptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables prosaposin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prosaposin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prosaposin receptor GPR37
    Names
    ETBR-LP-1
    G protein-coupled receptor 37 (endothelin receptor type B-like)
    Parkin-associated endothelin receptor-like receptor
    endothelin B receptor-like protein 1
    probable G-protein coupled receptor 37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005302.5NP_005293.1  prosaposin receptor GPR37 precursor

      See identical proteins and their annotated locations for NP_005293.1

      Status: REVIEWED

      Source sequence(s)
      AC004925, AF017262
      Consensus CDS
      CCDS5792.1
      UniProtKB/Swiss-Prot
      A4D0Y6, O00348, O14768, O15354, Q8TD39
      Related
      ENSP00000306449.2, ENST00000303921.3
      Conserved Domains (1) summary
      cd15127
      Location:262560
      7tmA_GPR37; G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      124743885..124765792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      126061240..126083145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)