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    SLC36A3 solute carrier family 36 member 3 [ Homo sapiens (human) ]

    Gene ID: 285641, updated on 17-Jun-2019

    Summary

    Official Symbol
    SLC36A3provided by HGNC
    Official Full Name
    solute carrier family 36 member 3provided by HGNC
    Primary source
    HGNC:HGNC:19659
    See related
    Ensembl:ENSG00000186334 MIM:608332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAT3; TRAMD2; tramdorin2
    Expression
    Restricted expression toward testis (RPKM 4.0) See more
    Orthologs

    Genomic context

    See SLC36A3 in Genome Data Viewer
    Location:
    5q33.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (151276358..151303766, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150655926..150683334, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 69 Neighboring gene uncharacterized LOC105378230 Neighboring gene GM2 ganglioside activator Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 5 Neighboring gene solute carrier family 36 member 2 Neighboring gene uncharacterized LOC105378234 Neighboring gene mediator complex subunit 13 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ16658, MGC119638, MGC119639, MGC119641

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amino acid:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proton transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    L-alanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proline transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proton transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proton-coupled amino acid transporter 3
    Names
    proton/amino acid transporter 3
    solute carrier family 36 (proton/amino acid symporter), member 3
    tramdorin 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145017.2NP_001138489.1  proton-coupled amino acid transporter 3 isoform 1

      See identical proteins and their annotated locations for NP_001138489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC008385, BC101092
      Consensus CDS
      CCDS47316.1
      UniProtKB/Swiss-Prot
      Q495N2
      Related
      ENSP00000366942.3, ENST00000377713.3
      Conserved Domains (1) summary
      cl00456
      Location:41492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_181774.4NP_861439.3  proton-coupled amino acid transporter 3 isoform 2

      See identical proteins and their annotated locations for NP_861439.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has the identical N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC008385, BC101095
      Consensus CDS
      CCDS4314.1
      UniProtKB/Swiss-Prot
      Q495N2
      Related
      ENSP00000334750.3, ENST00000335230.7
      Conserved Domains (1) summary
      cl00456
      Location:41451
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      151276358..151303766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537627.3XP_011535929.1  proton-coupled amino acid transporter 3 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:41425
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_011537633.1XP_011535935.1  proton-coupled amino acid transporter 3 isoform X4

      Conserved Domains (1) summary
      cl00456
      Location:42288
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_011537631.2XP_011535933.1  proton-coupled amino acid transporter 3 isoform X3

      See identical proteins and their annotated locations for XP_011535933.1

      Conserved Domains (1) summary
      cl00456
      Location:13336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. XM_011537630.2XP_011535932.1  proton-coupled amino acid transporter 3 isoform X3

      See identical proteins and their annotated locations for XP_011535932.1

      Conserved Domains (1) summary
      cl00456
      Location:13336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. XM_011537629.3XP_011535931.1  proton-coupled amino acid transporter 3 isoform X2

      Conserved Domains (1) summary
      cl00456
      Location:41327
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    6. XM_011537634.3XP_011535936.1  proton-coupled amino acid transporter 3 isoform X5

      Conserved Domains (1) summary
      cl00456
      Location:41163
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RNA

    1. XR_427775.3 RNA Sequence

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