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    HTR3E 5-hydroxytryptamine receptor 3E [ Homo sapiens (human) ]

    Gene ID: 285242, updated on 17-Jun-2019

    Summary

    Official Symbol
    HTR3Eprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 3Eprovided by HGNC
    Primary source
    HGNC:HGNC:24005
    See related
    Ensembl:ENSG00000186038 MIM:610123
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT3E; 5-HT3-E; 5-HT3c1
    Summary
    This locus encodes a 5-hydroxytryptamine (serotonin) receptor subunit. The encoded protein, subunit E, may play a role in neurotransmission in myenteric neurons. Genes encoding subunits C, D and E form a cluster on chromosome 3. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Feb 2012]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See HTR3E in Genome Data Viewer
    Location:
    3q27.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (184097064..184106995)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (183814852..183824783)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 3C Neighboring gene uncharacterized LOC105374249 Neighboring gene 5-hydroxytryptamine receptor 3C2, pseudogene Neighboring gene HTR3E antisense RNA 1 Neighboring gene heat shock protein 90 alpha family class A member 5, pseudogene Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Ligand-gated ion channel transport, organism-specific biosystem (from REACTOME)
      Ligand-gated ion channel transport, organism-specific biosystemLigand-gated ion channels (LGICs) are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (Purves, 2001).
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC120035, MGC120036, MGC120037

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to extracellular ligand-gated ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serotonin-gated cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nervous system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 3E
    Names
    5-hydroxytryptamine (serotonin) receptor 3, family member E
    5-hydroxytryptamine (serotonin) receptor 3E, ionotropic
    5-hydroxytryptamine receptor 3 subunit E

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012452.1 RefSeqGene

      Range
      5001..11817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256613.1NP_001243542.1  5-hydroxytryptamine receptor 3E isoform d precursor

      See identical proteins and their annotated locations for NP_001243542.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' UTR and coding region, compared to variant 1. These differences result in translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC131235, DQ644022
      Consensus CDS
      CCDS58868.1
      UniProtKB/Swiss-Prot
      A5X5Y0
      Related
      ENSP00000401444.2, ENST00000415389.6
      Conserved Domains (2) summary
      pfam02931
      Location:55247
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:254353
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. NM_001256614.1NP_001243543.1  5-hydroxytryptamine receptor 3E isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a longer protein (isoform e), compared to isoform a.
      Source sequence(s)
      AC131235, AY159813, DQ644022, EU165354
      Consensus CDS
      CCDS58871.1
      UniProtKB/Swiss-Prot
      A5X5Y0
      Related
      ENSP00000406050.2, ENST00000440596.2
      Conserved Domains (2) summary
      pfam02931
      Location:70273
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:280379
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    3. NM_182589.2NP_872395.2  5-hydroxytryptamine receptor 3E isoform a

      See identical proteins and their annotated locations for NP_872395.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC131235, AY159813
      Consensus CDS
      CCDS3251.1
      UniProtKB/Swiss-Prot
      A5X5Y0
      Related
      ENSP00000335511.2, ENST00000335304.6
      Conserved Domains (2) summary
      pfam02931
      Location:70262
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:269368
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    4. NM_198313.2NP_938055.1  5-hydroxytryptamine receptor 3E isoform c precursor

      See identical proteins and their annotated locations for NP_938055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the 5' UTR and coding region, compared to variant 1. This variant encodes isoform c, which has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC131235, AY349352, DQ644022
      Consensus CDS
      CCDS58869.1
      UniProtKB/Swiss-Prot
      A5X5Y0
      Related
      ENSP00000401900.2, ENST00000425359.6
      Conserved Domains (2) summary
      pfam02931
      Location:55232
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:239338
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    5. NM_198314.2NP_938056.1  5-hydroxytryptamine receptor 3E isoform b

      See identical proteins and their annotated locations for NP_938056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AC131235, AY159813, AY349353, DQ644022
      Consensus CDS
      CCDS58870.1
      UniProtKB/Swiss-Prot
      A5X5Y0
      Related
      ENSP00000395833.2, ENST00000436361.6
      Conserved Domains (2) summary
      pfam02931
      Location:70247
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:254353
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      184097064..184106995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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