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    GPR26 G protein-coupled receptor 26 [ Homo sapiens (human) ]

    Gene ID: 2849, updated on 17-Jun-2019

    Summary

    Official Symbol
    GPR26provided by HGNC
    Official Full Name
    G protein-coupled receptor 26provided by HGNC
    Primary source
    HGNC:HGNC:4481
    See related
    Ensembl:ENSG00000154478 MIM:604847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
    Expression
    Restricted expression toward brain (RPKM 2.1) See more
    Orthologs

    Genomic context

    See GPR26 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (123666355..123697399)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125425871..125456915)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2641 Neighboring gene VISTA enhancer hs578 Neighboring gene uncharacterized LOC105378530 Neighboring gene uncharacterized LOC105378532 Neighboring gene uncharacterized LOC105378533 Neighboring gene carboxypeptidase X, M14 family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33774, MGC138216, DKFZp761H2121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 26

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051571.1 RefSeqGene

      Range
      5001..36045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_153442.4NP_703143.1  G-protein coupled receptor 26

      See identical proteins and their annotated locations for NP_703143.1

      Status: REVIEWED

      Source sequence(s)
      AC009987, AI076749, AJ505757, AK091093
      Consensus CDS
      CCDS7636.1
      UniProtKB/Swiss-Prot
      Q8NDV2
      Related
      ENSP00000284674.1, ENST00000284674.1
      Conserved Domains (1) summary
      cd15219
      Location:7305
      7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      123666355..123697399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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