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    ZNF780A zinc finger protein 780A [ Homo sapiens (human) ]

    Gene ID: 284323, updated on 15-Jun-2019

    Summary

    Official Symbol
    ZNF780Aprovided by HGNC
    Official Full Name
    zinc finger protein 780Aprovided by HGNC
    Primary source
    HGNC:HGNC:27603
    See related
    Ensembl:ENSG00000197782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF780
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), lymph node (RPKM 2.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF780A in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (40069008..40091706, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40575059..40596845, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PAT1 homolog 1, processing body mRNA decay factor pseudogene Neighboring gene zinc finger protein 780B Neighboring gene vomeronasal 1 receptor 96 pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010880.2NP_001010880.2  zinc finger protein 780A isoform b

      See identical proteins and their annotated locations for NP_001010880.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK091274, BU685481, DA758840, DB097567
      Consensus CDS
      CCDS33026.2
      UniProtKB/Swiss-Prot
      O75290
      Related
      ENSP00000341507.5, ENST00000340963.9
      Conserved Domains (5) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:219595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:376400
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001142577.1NP_001136049.1  zinc finger protein 780A isoform a

      See identical proteins and their annotated locations for NP_001136049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK091274, BC021982, BU685481, DA436454, DA758840
      Consensus CDS
      CCDS46079.1
      UniProtKB/TrEMBL
      Q05CQ7
      Related
      ENSP00000400997.1, ENST00000455521.5
      Conserved Domains (5) summary
      smart00349
      Location:667
      KRAB; krueppel associated box
      COG5048
      Location:220596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:377401
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001142578.1NP_001136050.1  zinc finger protein 780A isoform b

      See identical proteins and their annotated locations for NP_001136050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK091274, BC021982, BU685481, DA758840
      Consensus CDS
      CCDS33026.2
      UniProtKB/Swiss-Prot
      O75290
      UniProtKB/TrEMBL
      Q05CQ7
      Conserved Domains (5) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:219595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:376400
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001142579.2NP_001136051.1  zinc finger protein 780A isoform c

      See identical proteins and their annotated locations for NP_001136051.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR and 3' coding region, uses an alternate in-frame splice site in its mid coding region, and includes an alternate exon containing a distinct translation start codon, compared to variant 1. The resulting isoform (c) has distinct N- and C-termini, and is shorter than isoform a.
      Source sequence(s)
      AC005614, AI638558, AK131328, AW243188
      Consensus CDS
      CCDS46078.1
      UniProtKB/Swiss-Prot
      O75290
      Related
      ENSP00000416294.1, ENST00000414720.6
      Conserved Domains (2) summary
      smart00349
      Location:2282
      KRAB; krueppel associated box
      pfam01352
      Location:2261
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      40069008..40091706 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723150.4XP_006723213.1  zinc finger protein 780A isoform X3

      See identical proteins and their annotated locations for XP_006723213.1

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:667
      KRAB; krueppel associated box
      COG5048
      Location:220596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:377401
      zf-H2C2_2; Zinc-finger double domain
    2. XM_024451454.1XP_024307222.1  zinc finger protein 780A isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:2283
      KRAB; krueppel associated box
      COG5048
      Location:236612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:196220
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017026619.2XP_016882108.1  zinc finger protein 780A isoform X4

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:219595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:376400
      zf-H2C2_2; Zinc-finger double domain
    4. XM_017026616.2XP_016882105.1  zinc finger protein 780A isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:2282
      KRAB; krueppel associated box
      COG5048
      Location:235611
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:195219
      zf-H2C2_2; Zinc-finger double domain
    5. XM_017026618.2XP_016882107.1  zinc finger protein 780A isoform X4

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:666
      KRAB; krueppel associated box
      COG5048
      Location:219595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335355
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:376400
      zf-H2C2_2; Zinc-finger double domain
    6. XM_005258773.3XP_005258830.1  zinc finger protein 780A isoform X3

      See identical proteins and their annotated locations for XP_005258830.1

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:667
      KRAB; krueppel associated box
      COG5048
      Location:220596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:377401
      zf-H2C2_2; Zinc-finger double domain
    7. XM_024451457.1XP_024307225.1  zinc finger protein 780A isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:2283
      KRAB; krueppel associated box
      COG5048
      Location:236612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:196220
      zf-H2C2_2; Zinc-finger double domain
    8. XM_024451458.1XP_024307226.1  zinc finger protein 780A isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:2282
      KRAB; krueppel associated box
      COG5048
      Location:235611
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351371
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:195219
      zf-H2C2_2; Zinc-finger double domain
    9. XM_011526771.3XP_011525073.1  zinc finger protein 780A isoform X3

      See identical proteins and their annotated locations for XP_011525073.1

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:667
      KRAB; krueppel associated box
      COG5048
      Location:220596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:377401
      zf-H2C2_2; Zinc-finger double domain
    10. XM_024451456.1XP_024307224.1  zinc finger protein 780A isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:2283
      KRAB; krueppel associated box
      COG5048
      Location:236612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:196220
      zf-H2C2_2; Zinc-finger double domain
    11. XM_011526772.3XP_011525074.1  zinc finger protein 780A isoform X3

      See identical proteins and their annotated locations for XP_011525074.1

      UniProtKB/Swiss-Prot
      O75290
      Conserved Domains (5) summary
      smart00349
      Location:667
      KRAB; krueppel associated box
      COG5048
      Location:220596
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:336356
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:645
      KRAB; KRAB box
      pfam13465
      Location:377401
      zf-H2C2_2; Zinc-finger double domain
    12. XM_024451455.1XP_024307223.1  zinc finger protein 780A isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:2283
      KRAB; krueppel associated box
      COG5048
      Location:236612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:352372
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:196220
      zf-H2C2_2; Zinc-finger double domain

    Reference GRCh38.p13 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p13 PATCHES

      Range
      344295..366086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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