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    NEK8 NIMA related kinase 8 [ Homo sapiens (human) ]

    Gene ID: 284086, updated on 12-May-2019

    Summary

    Official Symbol
    NEK8provided by HGNC
    Official Full Name
    NIMA related kinase 8provided by HGNC
    Primary source
    HGNC:HGNC:13387
    See related
    Ensembl:ENSG00000160602 MIM:609799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JCK; NPHP9; RHPD2; NEK12A
    Summary
    This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.8), lymph node (RPKM 2.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See NEK8 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (28727899..28742766)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27055822..27069784)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene ribosomal protein L23a Neighboring gene small nucleolar RNA, C/D box 4B Neighboring gene TLC domain containing 1 Neighboring gene TNF receptor associated factor 4 Neighboring gene family with sequence similarity 222 member B Neighboring gene ribosomal protein L31 pseudogene 58

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138445

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    ciliary base IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary inversin compartment IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek8
    Names
    NIMA (never in mitosis gene a)- related kinase 8
    NIMA-family kinase NEK8
    NIMA-related kinase 12a
    nephrocystin 9
    never in mitosis A-related kinase 8
    nimA-related protein kinase 8
    nima-related protein kinase 12a
    serine/thrionine-protein kinase NEK8
    NP_835464.1
    XP_011522940.1
    XP_011522942.1
    XP_016879988.1
    XP_016879989.1
    XP_016879990.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012263.1 RefSeqGene

      Range
      4975..19642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_178170.3NP_835464.1  serine/threonine-protein kinase Nek8

      See identical proteins and their annotated locations for NP_835464.1

      Status: REVIEWED

      Source sequence(s)
      AC010761, AY242354, CV811826
      Consensus CDS
      CCDS32597.1
      UniProtKB/Swiss-Prot
      Q86SG6
      Related
      ENSP00000268766.6, ENST00000268766.11
      Conserved Domains (2) summary
      cd08220
      Location:3258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8
      cl27697
      Location:276657
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

      Range
      28727899..28742766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524638.3XP_011522940.1  serine/threonine-protein kinase Nek8 isoform X1

      Conserved Domains (4) summary
      smart00220
      Location:41280
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG5184
      Location:349694
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:39282
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8
      pfam00415
      Location:616665
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. XM_011524640.3XP_011522942.1  serine/threonine-protein kinase Nek8 isoform X2

      Conserved Domains (4) summary
      smart00220
      Location:41280
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG5184
      Location:300681
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:39282
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8
      pfam00415
      Location:603652
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    3. XM_017024501.1XP_016879990.1  serine/threonine-protein kinase Nek8 isoform X5

      Related
      ENSP00000465859.1, ENST00000543014.1
    4. XM_017024500.2XP_016879989.1  serine/threonine-protein kinase Nek8 isoform X4

    5. XM_017024499.2XP_016879988.1  serine/threonine-protein kinase Nek8 isoform X3

    RNA

    1. XR_001752497.2 RNA Sequence

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