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    GPR12 G protein-coupled receptor 12 [ Homo sapiens (human) ]

    Gene ID: 2835, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GPR12provided by HGNC
    Official Full Name
    G protein-coupled receptor 12provided by HGNC
    Primary source
    HGNC:HGNC:4466
    See related
    Ensembl:ENSG00000132975 MIM:600752; AllianceGenome:HGNC:4466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPCR12; GPCR21; PPP1R84
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 3.0) and salivary gland (RPKM 0.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR12 in Genome Data Viewer
    Location:
    13q12.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (26755200..26760786, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (25969158..25974743, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (27329337..27334923, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene WASP family member 3 Neighboring gene RPS3A pseudogene 44 Neighboring gene NANOG hESC enhancer GRCh37_chr13:27232594-27233188 Neighboring gene uncharacterized LOC107984597 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27269807-27270328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27316809-27317475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27359105-27359720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5190 Neighboring gene FGFR1 oncogene partner 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:27541783-27542642 Neighboring gene ribosomal protein S21 pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural insight into the constitutive activity of human orphan receptor GPR12. Li H, et al. Sci Bull (Beijing), 2023 Jan 15. PMID 36593162
    2. GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells. Zhang M, et al. Thorac Cancer, 2021 May. PMID 33742771, Free PMC Article
    3. Cannabidiol, a novel inverse agonist for GPR12. Brown KJ, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28888984, Free PMC Article
    4. Involvement of GPR12 in the regulation of cell proliferation and survival. Lu X, et al. Mol Cell Biochem, 2012 Jul. PMID 22430950
    5. Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. Uhlenbrock K, et al. Cell Physiol Biochem, 2003. PMID 12649592

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exosomal miR-105-5p derived from bladder cancer stem cells targets for GPR12 to promote the malignancy of bladder cancer.
      Title: Exosomal miR-105-5p derived from bladder cancer stem cells targets for GPR12 to promote the malignancy of bladder cancer.
    2. Structural insight into the constitutive activity of human orphan receptor GPR12.
      Title: Structural insight into the constitutive activity of human orphan receptor GPR12.
    3. GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells.
      Title: GPR12 inhibits migration and promotes apoptosis in esophageal cancer and hypopharyngeal cancer cells.
    4. Since we have demonstrated that CBD is an inverse agonist for GPR12, this provides novel mechanism of action for CBD, and an initial chemical scaffold upon which highly potent and efficacious agents acting on GPR12 may be developed with the ultimate goal of blocking cancer metastasis.
      Title: Cannabidiol, a novel inverse agonist for GPR12.
    5. GPR12 may play a role in cell proliferation and survival
      Title: Involvement of GPR12 in the regulation of cell proliferation and survival.
    6. control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor
      Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ18149, FLJ97704, MGC138349, MGC138351

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 12
    Names
    protein phosphatase 1, regulatory subunit 84

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005288.4 → NP_005279.1  G-protein coupled receptor 12

      See identical proteins and their annotated locations for NP_005279.1

      Status: VALIDATED

      Source sequence(s)
      AK290220, AL159978, AW015633
      Consensus CDS
      CCDS9319.1
      UniProtKB/Swiss-Prot
      P47775, Q5T8P3
      UniProtKB/TrEMBL
      A8K2F5, Q6NWS7, Q6NWS8
      Related
      ENSP00000384932.3, ENST00000405846.5
      Conserved Domains (1) summary
      cd15961
      Location:45 → 312
      7tmA_GPR12; G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      26755200..26760786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005266360.3 → XP_005266417.1  G-protein coupled receptor 12 isoform X1

      See identical proteins and their annotated locations for XP_005266417.1

      UniProtKB/TrEMBL
      B4DG25
      Conserved Domains (1) summary
      pfam00001
      Location:1 → 142
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      25969158..25974743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374470.1 → XP_054230445.1  G-protein coupled receptor 12 isoform X1

      UniProtKB/TrEMBL
      B4DG25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47775.1 GenPept UniProtKB/Swiss-Prot:P47775

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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