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    KRT8 keratin 8 [ Bos taurus (domestic cattle) ]

    Gene ID: 281269, updated on 5-Sep-2025
    Official Symbol
    KRT8provided by VGNC
    Official Full Name
    keratin 8provided by VGNC
    Primary source
    VGNC:VGNC:50407
    See related
    EnsemblRapid:ENSBTAG00070034541
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    KRT2-8
    Orthologs
    human mouse all
    NEW
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    See KRT8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (27040267..27047717)

    Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene keratin 18 Neighboring gene uncharacterized LOC104976949 Neighboring gene uncharacterized LOC132345257 Neighboring gene keratin 78

    Genomic Sequence:
    NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Related articles in PubMed

    1. Cytokeratin expression in simple epithelia. II. cDNA cloning and sequence characteristics of bovine cytokeratin A (no. 8). Magin TM, et al. Differentiation, 1986. PMID 2422084
    2. Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines. Duncan A, et al. Reprod Biol Endocrinol, 2012 Oct 31. PMID 23113883, Free PMC Article
    3. Effects of Intrauterine Growth Restriction During Late Pregnancy on the Development of the Ovine Fetal Thymus and the T-Lymphocyte Subpopulation. Liu Y, et al. Am J Reprod Immunol, 2015 Jul. PMID 25708257
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells.
      Title: Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines.
    Submit: New GeneRIF Correction

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in keratinization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    keratin, type II cytoskeletal 8
    Names
    CK-8
    K8
    KERA
    cytokeratin 8
    cytokeratin-A
    type-II keratin Kb8

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033610.1 → NP_001028782.1  keratin, type II cytoskeletal 8

      See identical proteins and their annotated locations for NP_001028782.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103339
      UniProtKB/Swiss-Prot
      P05786, Q3SYX7
      UniProtKB/TrEMBL
      F1MU12
      Related
      ENSBTAP00070047376.1, ENSBTAT00070077626.1
      Conserved Domains (4) summary
      pfam00038
      Location:97 → 408
      Filament; Intermediate filament protein
      pfam04732
      Location:9 → 63
      Filament_head; Intermediate filament head (DNA binding) region
      pfam16208
      Location:18 → 94
      Keratin_2_head; Keratin type II head
      cl23720
      Location:308 → 377
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      27040267..27047717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05786.3 GenPept UniProtKB/Swiss-Prot:P05786

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials