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    GNAI1 G protein subunit alpha i1 [ Homo sapiens (human) ]

    Gene ID: 2770, updated on 19-Sep-2024

    Summary

    Official Symbol
    GNAI1provided by HGNC
    Official Full Name
    G protein subunit alpha i1provided by HGNC
    Primary source
    HGNC:HGNC:4384
    See related
    Ensembl:ENSG00000127955 MIM:139310; AllianceGenome:HGNC:4384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Gi; HG1B; NEDHISB
    Summary
    Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GNAI1 in Genome Data Viewer
    Location:
    7q21.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (80134831..80226181)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (81386157..81477526)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (79764147..79855497)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:79649082-79649587 Neighboring gene ribosomal protein L10 pseudogene 11 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:79756995-79757534 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:79794160-79794976 Neighboring gene uncharacterized LOC107986743 Neighboring gene RNA, 7SL, cytoplasmic 869, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:79912787-79913288 Neighboring gene uncharacterized LOC107986744

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2023-03-28)

    ClinGen Genome Curation Page
    Haploinsufficency

    No evidence available (Last evaluated 2023-03-28)

    ClinGen Genome Curation PagePubMed

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated phosphorylation of WAVE2 requires both G(alpha)i-dependent and -independent pathways, and is conserved both in X4 and R5 viral infection of resting CD4 T cells and primary macrophages PubMed
    env HIV-1 gp120 induces IL-1beta release from macrophages in a time- and concentration-dependent manner through binding to the chemokine receptor CCR5 and coupling to G(i)alpha protein PubMed
    env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D2 dopamine receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G protein-coupled serotonin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTPase activity TAS
    Traceable Author Statement
    more info
     
    enables adenylate cyclase regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to forskolin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cholesterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cAMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to peptide hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to prostaglandin E IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of heterotrimeric G-protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein G(i) subunit alpha-1
    Names
    Gi1 protein alpha subunit
    adenylate cyclase-inhibiting G alpha protein
    guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
    heterotrimeric guanine nucleotide-binding protein 1B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256414.2NP_001243343.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2

      See identical proteins and their annotated locations for NP_001243343.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC080066, AK304442, BC026326
      Consensus CDS
      CCDS59061.1
      UniProtKB/Swiss-Prot
      P63096
      Related
      ENSP00000410572.2, ENST00000457358.7
      Conserved Domains (1) summary
      cd00066
      Location:1296
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    2. NM_002069.6NP_002060.4  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1

      See identical proteins and their annotated locations for NP_002060.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004159, AC080066
      Consensus CDS
      CCDS5595.1
      UniProtKB/Swiss-Prot
      A8KA88, B4E2V1, C9J3A4, P04898, P11015, P31871, P63096, Q5U074, Q8TAN5, Q9UGA4
      Related
      ENSP00000497260.1, ENST00000649796.2
      Conserved Domains (1) summary
      cd00066
      Location:34348
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      80134831..80226181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      81386157..81477526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)