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    GML glycosylphosphatidylinositol anchored molecule like [ Homo sapiens (human) ]

    Gene ID: 2765, updated on 10-Dec-2024

    Summary

    Official Symbol
    GMLprovided by HGNC
    Official Full Name
    glycosylphosphatidylinositol anchored molecule likeprovided by HGNC
    Primary source
    HGNC:HGNC:4375
    See related
    Ensembl:ENSG00000104499 MIM:602370; AllianceGenome:HGNC:4375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LY6DL
    Summary
    Predicted to be involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; and negative regulation of cell population proliferation. Predicted to be located in plasma membrane. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See GML in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142834801..142846851)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143978146..143990184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143916217..143928267)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene LYNX1-SLURP2 readthrough Neighboring gene Ly6/neurotoxin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19608 Neighboring gene lymphocyte antigen 6 family member D Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:143896321-143897520 Neighboring gene zinc finger HIT-type containing 1 pseudogene 1 Neighboring gene CYP11B1 recombination region Neighboring gene CYP11B1 promoter Neighboring gene cytochrome P450 family 11 subfamily B member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of glycosylphosphatidylinositol anchored molecule like protein (GML) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    glycosyl-phosphatidylinositol-anchored molecule-like protein
    Names
    GPI anchored molecule like protein
    Glycosylphosphatidylinositol-anchored molecule-like protein
    glycosylphosphatidylinositol anchored molecule like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002066.3NP_002057.1  glycosyl-phosphatidylinositol-anchored molecule-like protein precursor

      See identical proteins and their annotated locations for NP_002057.1

      Status: VALIDATED

      Source sequence(s)
      AC083841, D84290
      Consensus CDS
      CCDS6391.1
      UniProtKB/Swiss-Prot
      A0AVF6, O00686, O00731, Q99445
      Related
      ENSP00000220940.1, ENST00000220940.2
      Conserved Domains (1) summary
      smart00134
      Location:29116
      LU; Ly-6 antigen / uPA receptor -like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      142834801..142846851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      143978146..143990184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)